Hepatoprotective and antiviral functions of silymarin components in hepatitis C virus infection.
作者信息
Polyak Stephen J, Ferenci Peter, Pawlotsky Jean-Michel
机构信息
Department of Laboratory Medicine, University of Washington, Seattle, WA 98104, USA.
出版信息
Hepatology. 2013 Mar;57(3):1262-71. doi: 10.1002/hep.26179.
Abstract
摘要
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2
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PLoS One. 2012;7(7):e41832. doi: 10.1371/journal.pone.0041832. Epub 2012 Jul 25.
3
Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial.
JAMA. 2012 Jul 18;308(3):274-82. doi: 10.1001/jama.2012.8265.
4
High-dose silibinin rescue treatment for HCV-infected patients showing suboptimal virologic response to standard combination therapy.
J Viral Hepat. 2012 Aug;19(8):547-53. doi: 10.1111/j.1365-2893.2011.01572.x. Epub 2011 Dec 29.
5
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Free Radic Biol Med. 2012 May 1;52(9):1658-65. doi: 10.1016/j.freeradbiomed.2012.02.008. Epub 2012 Feb 15.
6
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8
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9
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