Heart Research Centre, Royal Melbourne Hospital, PO Box 2137, Post Office, Melbourne, VIC 3050, Australia.
Heart. 2013 May;99(9):620-5. doi: 10.1136/heartjnl-2012-303022. Epub 2012 Dec 4.
To investigate whether attendance at cardiac rehabilitation (CR) independently predicts all-cause mortality over 14 years and whether there is a dose-response relationship between the proportion of CR sessions attended and long-term mortality.
Retrospective cohort study.
CR programmes in Victoria, Australia
The sample comprised 544 men and women eligible for CR following myocardial infarction, coronary artery bypass surgery or percutaneous interventions. Participants were tracked 4 months after hospital discharge to ascertain CR attendance status.
All-cause mortality at 14 years ascertained through linkage to the Australian National Death Index.
In total, 281 (52%) men and women attended at least one CR session. There were few significant differences between non-attenders and attenders. After adjustment for age, sex, diagnosis, employment, diabetes and family history, the mortality risk for non-attenders was 58% greater than for attenders (HR=1.58, 95% CI 1.16 to 2.15). Participants who attended <25% of sessions had a mortality risk more than twice that of participants attending ≥ 75% of sessions (OR=2.57, 95% CI 1.04 to 6.38). This association was attenuated after adjusting for current smoking (OR=2.06, 95% CI 0.80 to 5.29).
This study provides further evidence for the long-term benefits of CR in a contemporary, heterogeneous population. While a dose-response relationship may exist between the number of sessions attended and long-term mortality, this relationship does not occur independently of smoking differences. CR practitioners should encourage smokers to attend CR and provide support for smoking cessation.
探讨在 14 年的时间里,参加心脏康复(CR)是否能独立预测全因死亡率,以及参加 CR 次数与长期死亡率之间是否存在剂量-反应关系。
回顾性队列研究。
澳大利亚维多利亚州的 CR 项目。
该样本包括 544 名符合 CR 条件的男性和女性,他们在心肌梗死、冠状动脉旁路手术或经皮介入治疗后。在出院后 4 个月对参与者进行跟踪,以确定 CR 的出席情况。
通过与澳大利亚国家死亡索引链接,确定 14 年时的全因死亡率。
共有 281 名(52%)男性和女性参加了至少一次 CR 课程。未参加者和参加者之间几乎没有显著差异。在调整了年龄、性别、诊断、就业、糖尿病和家族史后,未参加者的死亡率比参加者高 58%(HR=1.58,95%CI 1.16 至 2.15)。参加者参加的课程不足 25%的,其死亡率风险是参加者参加≥75%课程的两倍以上(OR=2.57,95%CI 1.04 至 6.38)。在调整了当前吸烟状况后(OR=2.06,95%CI 0.80 至 5.29),这种关联减弱了。
本研究为当代异质人群中 CR 的长期效益提供了进一步的证据。虽然参加课程的次数与长期死亡率之间可能存在剂量-反应关系,但这种关系并不独立于吸烟差异。CR 从业者应鼓励吸烟者参加 CR,并为戒烟提供支持。