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bHLH 因子 Dpn 和 E(spl) 复合物的成员介导 Notch 信号通路的功能，调节翼盘发育过程中的细胞增殖。

The bHLH factors Dpn and members of the E(spl) complex mediate the function of Notch signalling regulating cell proliferation during wing disc development.

机构信息

Centro de Biología Molecular Severo Ochoa (CSIC/UAM) C/Nicolás Cabrera 1 , 28049 Madrid , Spain.

出版信息

Biol Open. 2012 Jul 15;1(7):667-76. doi: 10.1242/bio.20121172. Epub 2012 May 30.

DOI:10.1242/bio.20121172
PMID:23213460
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3507296/
Abstract

The Notch signalling pathway plays an essential role in the intricate control of cell proliferation and pattern formation in many organs during animal development. In addition, mutations in most members of this pathway are well characterized and frequently lead to tumour formation. The Drosophila imaginal wing discs have provided a suitable model system for the genetic and molecular analysis of the different pathway functions. During disc development, Notch signalling at the presumptive wing margin is necessary for the restricted activation of genes required for pattern formation control and disc proliferation. Interestingly, in different cellular contexts within the wing disc, Notch can either promote cell proliferation or can block the G1-S transition by negatively regulating the expression of dmyc and bantam micro RNA. The target genes of Notch signalling that are required for these functions have not been identified. Here, we show that the Hes vertebrate homolog, deadpan (dpn), and the Enhancer-of-split complex (E(spl)C) genes act redundantly and cooperatively to mediate the Notch signalling function regulating cell proliferation during wing disc development.

摘要

Notch 信号通路在动物发育过程中许多器官的细胞增殖和形态形成的复杂调控中发挥着重要作用。此外，该通路的大多数成员的突变都得到了很好的描述，并且经常导致肿瘤形成。果蝇的 imaginal 翅盘为 Notch 信号通路的不同功能的遗传和分子分析提供了一个合适的模型系统。在盘发育过程中， Notch 信号在假定的翅缘处对于控制形态发生和盘增殖所需的基因的受限激活是必需的。有趣的是，在翅盘中的不同细胞环境中， Notch 可以通过负调控 dmyc 和 bantam microRNA 的表达来促进细胞增殖或阻止 G1-S 过渡。这些功能所需的 Notch 信号的靶基因尚未被确定。在这里，我们表明，Hes 脊椎动物同源物 deadpan (dpn) 和 Enhancer-of-split complex (E(spl)C) 基因冗余且协同作用，以介导 Notch 信号通路在 wing disc 发育过程中调节细胞增殖的功能。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c44/3507296/60c8276841e9/bio-01-07-667-f07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c44/3507296/c30a094b1f52/bio-01-07-667-f01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c44/3507296/cf440ac3a438/bio-01-07-667-f02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c44/3507296/c5ca81acb433/bio-01-07-667-f03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c44/3507296/bc995b7f34a2/bio-01-07-667-f04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c44/3507296/5aa96f98a562/bio-01-07-667-f05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c44/3507296/920cb68106e2/bio-01-07-667-f06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c44/3507296/60c8276841e9/bio-01-07-667-f07.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c44/3507296/c30a094b1f52/bio-01-07-667-f01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c44/3507296/cf440ac3a438/bio-01-07-667-f02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c44/3507296/c5ca81acb433/bio-01-07-667-f03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c44/3507296/bc995b7f34a2/bio-01-07-667-f04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c44/3507296/5aa96f98a562/bio-01-07-667-f05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c44/3507296/920cb68106e2/bio-01-07-667-f06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c44/3507296/60c8276841e9/bio-01-07-667-f07.jpg

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Transcriptional control of stem cell maintenance in the Drosophila intestine.果蝇肠道干细胞维持的转录控制。
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3
Neural stem cell transcriptional networks highlight genes essential for nervous system development.
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The conserved C2 phospholipid-binding domain in Delta contributes to robust Notch signalling.Delta 中保守的 C2 磷脂结合结构域有助于稳健的 Notch 信号传导。
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