Thouvenot Eric, Mura Frédéric, De Verdal Marie, Carlander Bertrand, Charif Mahmoud, Schneider Christelle, Navarre Sophie, Camu William
Neurology Department, Hôpital Carémeau, 9 Place Robert Debré, 30029 Nimes Cedex 9, France.
Mult Scler Int. 2012;2012:372361. doi: 10.1155/2012/372361. Epub 2012 Nov 19.
Background. Uveitis is 20 times more frequent in multiple sclerosis (MS) patients than in the general population. Methods. A retrospective study of local multiple sclerosis (n = 700) and uveitis cohorts (n = 450) described the ophthalmological and neurological characteristics of patients with multiple sclerosis and uveitis. Results. Uveitis and multiple sclerosis were associated in seven patients. The time intervals between diagnoses of MS and uveitis ranged from 6 months to 15 years. Analysis of the patients' characteristics revealed that multiple sclerosis was associated with an older age of onset than usually expected, that is, 39 years. Uveitis was bilateral in three cases and mainly posterior (5/10). Five patients presented with acute optic neuritis (two in one eye and three in both eyes). All eyes presenting with acute optic neuritis were also affected by uveitis (P = 0.02), though not simultaneously. Conclusion. The ipsilateral association between optic neuritis and uveitis in this series of patients with multiple sclerosis may suggest a reciprocal potentiation between optic neuritis and uveitis in multiple sclerosis.
背景。葡萄膜炎在多发性硬化症（MS）患者中的发病率比普通人群高20倍。方法。对当地的多发性硬化症患者队列（n = 700）和葡萄膜炎患者队列（n = 450）进行回顾性研究，描述了多发性硬化症合并葡萄膜炎患者的眼科和神经学特征。结果。7例患者同时患有葡萄膜炎和多发性硬化症。MS诊断与葡萄膜炎诊断之间的时间间隔为6个月至15年。对患者特征的分析显示，多发性硬化症的发病年龄比通常预期的要大，即39岁。葡萄膜炎3例为双侧，主要为后葡萄膜炎（5/10）。5例患者出现急性视神经炎（单眼2例，双眼3例）。所有出现急性视神经炎的眼睛也都受到葡萄膜炎的影响（P = 0.02），但并非同时发生。结论。在这一系列多发性硬化症患者中，视神经炎与葡萄膜炎的同侧关联可能提示多发性硬化症中视神经炎与葡萄膜炎之间存在相互增强作用。
