Wnt/β-连环蛋白：急性髓系白血病的一种新治疗方法。
Wnt/ß-catenin: a new therapeutic approach to acute myeloid leukemia.
作者信息
Kim Y, Thanendrarajan S, Schmidt-Wolf I G H
机构信息
Department of Internal Medicine III, Center for Integrated Oncology (CIO), University of Bonn, Sigmund-Freud-Straße 25, 53105 Bonn, Germany.
出版信息
Leuk Res Treatment. 2011;2011:428960. doi: 10.4061/2011/428960. Epub 2011 Dec 1.
Abstract
Recent studies have shown genetic and epigenetic aberrations resulting in aberrant activation of the Wingless-Int (Wnt) pathway, thus influencing the initiation and progression of acute myeloid leukemia (AML). Of major importance, these findings may lead to novel treatment strategies exploiting targeted modulation of Wnt signaling. This paper comprises the latest status of knowledge concerning the role of Wnt pathway alteration in AML and outlines future lines of research and their clinical perspectives.
摘要
最近的研究表明，基因和表观遗传异常会导致无翅型MMTV整合位点家族（Wnt）信号通路异常激活，从而影响急性髓系白血病（AML）的发生和发展。最重要的是，这些发现可能会带来利用Wnt信号靶向调控的新型治疗策略。本文阐述了关于Wnt信号通路改变在AML中作用的最新知识状况，并概述了未来的研究方向及其临床前景。
相似文献
1
Wnt/ß-catenin: a new therapeutic approach to acute myeloid leukemia.Wnt/β-连环蛋白：急性髓系白血病的一种新治疗方法。
Leuk Res Treatment. 2011;2011:428960. doi: 10.4061/2011/428960. Epub 2011 Dec 1.
2
Influencing the Wnt signaling pathway in multiple myeloma.影响多发性骨髓瘤中的 Wnt 信号通路。
Anticancer Res. 2011 Feb;31(2):725-30.
3
CD82 supports survival of childhood acute myeloid leukemia cells via activation of Wnt/β-catenin signaling pathway.CD82 通过激活 Wnt/β-catenin 信号通路来支持儿童急性髓系白血病细胞的存活。
Pediatr Res. 2019 Jun;85(7):1024-1031. doi: 10.1038/s41390-019-0370-3. Epub 2019 Mar 12.
4
HOTAIRM1 knockdown enhances cytarabine-induced cytotoxicity by suppression of glycolysis through the Wnt/β-catenin/PFKP pathway in acute myeloid leukemia cells.HOTAIRM1 敲低通过 Wnt/β-catenin/磷酸果糖激酶 P 途径抑制糖酵解增强阿糖胞苷诱导的急性髓系白血病细胞的细胞毒性。
Arch Biochem Biophys. 2020 Feb 15;680:108244. doi: 10.1016/j.abb.2019.108244. Epub 2020 Jan 2.
5
DIXDC1 promotes the growth of acute myeloid leukemia cells by upregulating the Wnt/β-catenin signaling pathway.DIXDC1 通过上调 Wnt/β-连环蛋白信号通路促进急性髓系白血病细胞的生长。
Biomed Pharmacother. 2018 Nov;107:1548-1555. doi: 10.1016/j.biopha.2018.08.144. Epub 2018 Sep 5.
6
Disruption of Wnt/β-Catenin Exerts Antileukemia Activity and Synergizes with FLT3 Inhibition in -Mutant Acute Myeloid Leukemia.Wnt/β-连环蛋白信号通路的破坏可发挥抗白血病作用，并与 FLT3 抑制在 - 突变型急性髓系白血病中协同作用。
Clin Cancer Res. 2018 May 15;24(10):2417-2429. doi: 10.1158/1078-0432.CCR-17-1556. Epub 2018 Feb 20.
7
A novel dipeptide type inhibitor of the Wnt/β-catenin pathway suppresses proliferation of acute myelogenous leukemia cells.一种新型的 Wnt/β-连环蛋白通路二肽抑制剂抑制急性髓系白血病细胞的增殖。
Biochem Biophys Res Commun. 2021 Jan 8;535:73-79. doi: 10.1016/j.bbrc.2020.12.027. Epub 2020 Dec 18.
8
Wnt signaling pathway is epigenetically regulated by methylation of Wnt antagonists in acute myeloid leukemia.在急性髓系白血病中，Wnt信号通路通过Wnt拮抗剂的甲基化受到表观遗传调控。
Leukemia. 2009 Sep;23(9):1658-66. doi: 10.1038/leu.2009.86. Epub 2009 Apr 23.
9
EZH2 mediates ATO-induced apoptosis in acute myeloid leukemia cell lines through the Wnt signaling pathway.EZH2通过Wnt信号通路介导三氧化二砷诱导的急性髓系白血病细胞系凋亡。
Tumour Biol. 2016 May;37(5):5919-23. doi: 10.1007/s13277-015-4463-2. Epub 2015 Nov 23.
10
LncRNA LINC00909 promotes cell proliferation and metastasis in pediatric acute myeloid leukemia via miR-625-mediated modulation of Wnt/β-catenin signaling.长链非编码 RNA LINC00909 通过 miR-625 介导的 Wnt/β-catenin 信号通路调控促进小儿急性髓系白血病细胞的增殖和转移。
Biochem Biophys Res Commun. 2020 Jun 30;527(3):654-661. doi: 10.1016/j.bbrc.2020.05.001. Epub 2020 May 15.
引用本文的文献
1
FOXN3-AS1: A Candidate Prognostic Marker and Epigenetic Target with Immunotherapeutic Implications in Acute Myeloid Leukemia.FOXN3-AS1：急性髓系白血病中一个具有预后意义的候选标志物及具有免疫治疗意义的表观遗传靶点
Curr Med Chem. 2024 Oct 11. doi: 10.2174/0109298673311108240926062214.
2
TIM-3 signaling hijacks the canonical Wnt/β-catenin pathway to maintain cancer stemness in acute myeloid leukemia.TIM-3 信号劫持经典的 Wnt/β-连环蛋白通路以维持急性髓系白血病中的癌症干性。
Blood Adv. 2023 May 23;7(10):2053-2065. doi: 10.1182/bloodadvances.2022008405.
3
Deciphering the role of Wnt signaling in acute myeloid leukemia prognosis: how alterations in DNA methylation come into play in patients' prognosis.解读Wnt信号通路在急性髓系白血病预后中的作用：DNA甲基化改变如何影响患者预后。
J Cancer Res Clin Oncol. 2020 Dec;146(12):3097-3109. doi: 10.1007/s00432-020-03407-3. Epub 2020 Sep 27.
4
SHP1 and SHP2 inhibition enhances the pro-differentiative effect of phorbol esters: an alternative approach against acute myeloid leukemia.SHP1 和 SHP2 抑制增强了佛波酯的促分化作用：一种对抗急性髓系白血病的替代方法。
J Exp Clin Cancer Res. 2019 Feb 14;38(1):80. doi: 10.1186/s13046-019-1097-z.
5
Molecular characterization of Wnt pathway and function of β-catenin overexpression in medulloblastoma cell lines.髓母细胞瘤细胞系中Wnt信号通路的分子特征及β-连环蛋白过表达的功能
Cytotechnology. 2018 Dec;70(6):1713-1722. doi: 10.1007/s10616-018-0260-2. Epub 2018 Oct 29.
6
Disruption of Wnt/β-Catenin Exerts Antileukemia Activity and Synergizes with FLT3 Inhibition in -Mutant Acute Myeloid Leukemia.Wnt/β-连环蛋白信号通路的破坏可发挥抗白血病作用，并与 FLT3 抑制在 - 突变型急性髓系白血病中协同作用。
Clin Cancer Res. 2018 May 15;24(10):2417-2429. doi: 10.1158/1078-0432.CCR-17-1556. Epub 2018 Feb 20.
7
β-catenin induces expression of prohibitin gene in acute leukemic cells.β-连环蛋白诱导急性白血病细胞中抑癌基因的表达。
Oncol Rep. 2017 Jun;37(6):3201-3208. doi: 10.3892/or.2017.5599. Epub 2017 Apr 25.
8
Targeting acute myeloid leukemia stem cell signaling by natural products.天然产物靶向急性髓系白血病干细胞信号通路
Mol Cancer. 2017 Jan 30;16(1):13. doi: 10.1186/s12943-016-0571-x.
9
Mesenchymal Stem and Progenitor Cells in Normal and Dysplastic Hematopoiesis-Masters of Survival and Clonality?正常和发育异常造血中的间充质干细胞和祖细胞——生存与克隆性的主宰？
Int J Mol Sci. 2016 Jun 27;17(7):1009. doi: 10.3390/ijms17071009.
10
Pharmacological targeting of β-catenin in normal karyotype acute myeloid leukemia blasts.在正常核型急性髓系白血病母细胞中对β-连环蛋白进行药理学靶向作用。
Haematologica. 2015 Feb;100(2):e49-52. doi: 10.3324/haematol.2014.113118. Epub 2014 Nov 7.
本文引用的文献
1
Differential niche and Wnt requirements during acute myeloid leukemia progression.急性髓系白血病进展过程中的差异龛位和 Wnt 需求。
Blood. 2011 Sep 8;118(10):2849-56. doi: 10.1182/blood-2011-03-345165. Epub 2011 Jul 15.
2
Increased in vivo efficacy of lenalidomide and thalidomide by addition of ethacrynic acid.加用依他尼酸增强来那度胺和沙利度胺的体内疗效。
In Vivo. 2011 May-Jun;25(3):325-33.
3
4
Influencing the Wnt signaling pathway in multiple myeloma.影响多发性骨髓瘤中的 Wnt 信号通路。
Anticancer Res. 2011 Feb;31(2):725-30.
5
Heterogeneous sensitivity of human acute myeloid leukemia to β-catenin down-modulation.人急性髓系白血病对β-连环蛋白下调的异质性敏感性。
Leukemia. 2011 May;25(5):770-780. doi: 10.1038/leu.2011.17. Epub 2011 Feb 22.
6
Increased in vivo efficacy of lenalidomide by addition of piroctone olamine.泊洛沙姆胺增强来那度胺在体内的疗效。
In Vivo. 2011 Jan-Feb;25(1):99-103.
7
Genome-wide screen reveals WNT11, a non-canonical WNT gene, as a direct target of ETS transcription factor ERG.全基因组筛选揭示 WNT11，一种非经典的 WNT 基因，是 ETS 转录因子 ERG 的直接靶标。
Oncogene. 2011 Apr 28;30(17):2044-56. doi: 10.1038/onc.2010.582. Epub 2011 Jan 17.
8
Proliferation and bone marrow engraftment of AML blasts is dependent on β-catenin signalling.AML 白血病细胞的增殖和骨髓植入依赖于β-连环蛋白信号通路。
Br J Haematol. 2011 Jan;152(2):164-74. doi: 10.1111/j.1365-2141.2010.08471.x. Epub 2010 Dec 1.
9
In vivo efficacy of griseofulvin against multiple myeloma.灰黄霉素治疗多发性骨髓瘤的体内疗效。
Leuk Res. 2011 Aug;35(8):1070-3. doi: 10.1016/j.leukres.2010.10.008. Epub 2010 Nov 26.
10
Acute myeloid leukemia is characterized by Wnt pathway inhibitor promoter hypermethylation.急性髓系白血病的特征是 Wnt 通路抑制剂启动子超甲基化。
Leuk Lymphoma. 2010 Sep;51(9):1711-9. doi: 10.3109/10428194.2010.496505.
Zotero 插件