Kim Y, Thanendrarajan S, Schmidt-Wolf I G H
Department of Internal Medicine III, Center for Integrated Oncology (CIO), University of Bonn, Sigmund-Freud-Straße 25, 53105 Bonn, Germany.
Leuk Res Treatment. 2011;2011:428960. doi: 10.4061/2011/428960. Epub 2011 Dec 1.
Recent studies have shown genetic and epigenetic aberrations resulting in aberrant activation of the Wingless-Int (Wnt) pathway, thus influencing the initiation and progression of acute myeloid leukemia (AML). Of major importance, these findings may lead to novel treatment strategies exploiting targeted modulation of Wnt signaling. This paper comprises the latest status of knowledge concerning the role of Wnt pathway alteration in AML and outlines future lines of research and their clinical perspectives.
最近的研究表明，基因和表观遗传异常会导致无翅型MMTV整合位点家族（Wnt）信号通路异常激活，从而影响急性髓系白血病（AML）的发生和发展。最重要的是，这些发现可能会带来利用Wnt信号靶向调控的新型治疗策略。本文阐述了关于Wnt信号通路改变在AML中作用的最新知识状况，并概述了未来的研究方向及其临床前景。
