Al-Khateeb Hani, Badheeb Ahmed, Haddad Husam, Marei Lina, Abbasi Salah
Medical Oncology Department, King Hussein Cancer Center, Al-Jubeiha, Amman 11941, Jordan.
Leuk Res Treatment. 2011;2011:523168. doi: 10.4061/2011/523168. Epub 2010 Dec 26.
Myeloid sarcoma (MS) is a neoplasm of immature granulocytes, monocytes, or both involving any extramedullary site. Twenty one patients with MS at diagnosis who were treated at King Hussein Cancer Center in Jordan were included in this retrospective study with a male to female ratio of 2 : 1. The most common site was the reticuloendothelial system. The most common morphology subtype was M2 (38%) and the most frequent chromosomal abnormality was trisomy 8. Twenty patients received induction chemotherapy; only 14 (70%) achieved complete remission. Median survival time was 24.7 months for the whole group and 58.6 months for patients who underwent allogenic bone marrow transplant. This paper showed that MS has frequent M2 morphology, carries chromosomal aberrations other than t(8;21), and requires aggressive therapy as a front line approach.
髓系肉瘤（MS）是一种由未成熟粒细胞、单核细胞或两者组成的肿瘤，可累及任何髓外部位。本回顾性研究纳入了21例在约旦侯赛因国王癌症中心确诊并接受治疗的MS患者，男女比例为2∶1。最常见的发病部位是网状内皮系统。最常见的形态学亚型是M2（38%），最常见的染色体异常是8号染色体三体。20例患者接受了诱导化疗，只有14例（70%）达到完全缓解。全组患者的中位生存时间为24.7个月，接受异基因骨髓移植的患者为58.6个月。本文表明，MS具有常见的M2形态，携带除t(8;21)以外的染色体畸变，需要积极的治疗作为一线治疗方法。
