Shah Kajal, Panchal Harsha, Patel Apurva
Department of Medical Oncology, Gujarat Cancer Research Institute, Ahmedabad, Gujrat, India.
Medical Oncology, Gujarat Cancer Research Institute, Ahmedabad, Gujrat, India.
South Asian J Cancer. 2021 Dec 31;10(4):251-254. doi: 10.1055/s-0041-1742079. eCollection 2021 Dec.
Myeloid sarcoma (MS) is a malignant extramedullary tumor consisting of immature cells of myeloid origin. It may precede, present concurrently or follow acute myeloid leukemia (AML) in de novo case or may also be present and might be the only manifestation of recurrent AML, myelodysplastic syndrome, or chronic myeloid leukemia. It frequently involves skin, orbit, bone, periosteum, lymph nodes, and gastrointestinal tract, soft tissue, central nervous system, and testis. Because of its different localization and symptoms, and the lack of diagnostic algorithm, MS is a real diagnostic challenge particularly in patients without initial bone marrow involvement. The correct diagnosis of MS is important for optimum therapy, which is often delayed because of a high misdiagnosis rate. We reported three cases of MS derived from spine presented with back pain, paraplegia, paraparesis, respectively, and reviewed the relevant literature.
髓系肉瘤（MS）是一种由髓系来源的未成熟细胞组成的恶性髓外肿瘤。在初发病例中，它可能先于急性髓系白血病（AML）出现、与AML同时出现或在AML之后出现，也可能出现在复发性AML、骨髓增生异常综合征或慢性髓系白血病中，且可能是唯一的表现形式。它常累及皮肤、眼眶、骨骼、骨膜、淋巴结、胃肠道、软组织、中枢神经系统和睾丸。由于其定位和症状各异，且缺乏诊断算法，MS尤其是在无初始骨髓受累的患者中是一项真正的诊断挑战。MS的正确诊断对于优化治疗很重要，由于误诊率高，治疗往往会延迟。我们报告了3例分别以背痛、截瘫、轻截瘫为表现的源自脊柱的MS病例，并对相关文献进行了回顾。
