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穹顶型：结肠腺癌的一种独特变体。

Dome-type: a distinctive variant of colonic adenocarcinoma.

作者信息

Puppa Giacomo, Molaro Mariella

机构信息

Service de Pathologie Clinique, Hôpitaux Universitaires de Genève, 1211 Geneva, Switzerland.

出版信息

Case Rep Pathol. 2012;2012:284064. doi: 10.1155/2012/284064. Epub 2012 Nov 19.

DOI:10.1155/2012/284064
PMID:23213588
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3507079/
Abstract

Introduction. Ten cases of dome-type adenocarcinoma of the colon have been reported so far. Most of them were presented as early lesions, with endoscopic and microscopic distinguishing features. Methods and Results. A raised plaque was removed from the right colon during colonoscopy in a 56-year-old man. Histopathological examination showed a cancerized adenoma invading the submucosa with several typical features of dome-type adenocarcinoma, in particular the associated prominent lymphoid tissue. Immunohistochemistry showed retention of the mismatch repair proteins MLH-1, MSH-2, MLH-6, and PMS-2. Conclusion. We report an additional case of dome-type adenocarcinoma of the colon as an early, low-risk, and microsatellite stable tumor, indicating that this particular histotype may deserve specific consideration for both classification and management.

摘要

引言。迄今为止，已报道了10例结肠穹窿型腺癌病例。其中大多数表现为早期病变，具有内镜和显微镜下的鉴别特征。方法与结果。一名56岁男性在结肠镜检查期间从右结肠切除了一个隆起的斑块。组织病理学检查显示为癌化腺瘤侵犯黏膜下层，具有穹窿型腺癌的几个典型特征，特别是伴有显著的淋巴组织。免疫组织化学显示错配修复蛋白MLH-1、MSH-2、MLH-6和PMS-2保留。结论。我们报告了另外一例结肠穹窿型腺癌，为早期、低风险且微卫星稳定的肿瘤，表明这种特殊的组织学类型在分类和管理方面可能值得特别考虑。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c939/3507079/319a05d4b955/CRIM.PATHOLOGY2012-284064.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c939/3507079/731ea565f242/CRIM.PATHOLOGY2012-284064.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c939/3507079/39b6e14cc2f8/CRIM.PATHOLOGY2012-284064.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c939/3507079/319a05d4b955/CRIM.PATHOLOGY2012-284064.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c939/3507079/731ea565f242/CRIM.PATHOLOGY2012-284064.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c939/3507079/39b6e14cc2f8/CRIM.PATHOLOGY2012-284064.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c939/3507079/319a05d4b955/CRIM.PATHOLOGY2012-284064.003.jpg

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本文引用的文献

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2
Dome-type colorectal carcinoma: a case report and review of the literature.穹顶型结直肠癌：一例报告并文献复习
Colorectal Dis. 2012 Jun;14(6):e360-2. doi: 10.1111/j.1463-1318.2011.02795.x.
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Dome-type carcinoma of the colon.结肠穹窿型癌
与肠道相关淋巴组织相关的结直肠上皮肿瘤
J Pathol Transl Med. 2020 Mar;54(2):135-145. doi: 10.4132/jptm.2019.11.06. Epub 2020 Jan 29.
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Diagn Pathol. 2015 Jul 9;10:92. doi: 10.1186/s13000-015-0305-1.
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Colorectal carcinoma with dome-like phenotype: an under-recognised subset of colorectal carcinoma?具有穹顶样表型的结直肠癌：一种未被充分认识的结直肠癌亚型？
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