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利用原子力显微镜研究有/无皮肤乳膏处理的正常和受损皮肤的摩擦和耐用性。

Friction and durability of virgin and damaged skin with and without skin cream treatment using atomic force microscopy.

机构信息

Nanoprobe Laboratory for Bio- & Nanotechnology and Biomimetics, The Ohio State University, 201 W 19th Ave., Columbus, OH 43210 USA.

出版信息

Beilstein J Nanotechnol. 2012;3:731-46. doi: 10.3762/bjnano.3.83. Epub 2012 Nov 8.

Abstract

Skin can be damaged by the environment easily. Skin cream is an effective and rapid way to moisten the skin by changing the skin surface properties. Rat skin and pig skin are common animal models for studies and were used as skin samples in this study. The nano- and macroscale friction and durability of damaged skin were measured and compared with those of virgin (intact/undamaged) skin. The effect of skin cream on friction and durability of damaged and virgin skin samples is discussed. The effects of velocity, normal load, relative humidity and number of cycles were studied. The nanoscale studies were performed by using atomic force microscope (AFM), and macroscale studies were performed by using a pin-on-disk (POD) reciprocating tribometer. It was found that damaged skin has different mechanical properties, surface roughness, contact angle, friction and durability compared to that of virgin skin. But similar changes occur after skin cream treatment. Rat and pig skin show similar trends in friction and durability.

摘要

皮肤很容易受到环境的伤害。皮肤膏是一种通过改变皮肤表面特性来有效快速滋润皮肤的方法。鼠皮和猪皮是常用于研究的常见动物模型,在本研究中被用作皮肤样本。测量并比较了受损皮肤和正常皮肤(完整/未受损)的纳米级和宏观级摩擦和耐用性。讨论了皮肤膏对受损和正常皮肤样本摩擦和耐用性的影响。研究了速度、法向载荷、相对湿度和循环次数的影响。纳米级研究使用原子力显微镜(AFM)进行,宏观级研究使用销盘(POD)往复式摩擦磨损试验机进行。结果表明,与正常皮肤相比,受损皮肤具有不同的机械性能、表面粗糙度、接触角、摩擦和耐用性。但在皮肤膏处理后会出现类似的变化。鼠皮和猪皮的摩擦和耐用性趋势相似。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d4b/3512123/94c4094c195d/Beilstein_J_Nanotechnol-03-731-g004.jpg

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