[乙醇脱氢酶1B（ADH1B）和乙醛脱氢酶2（ALDH-2）基因多态性与食管癌风险的相关性：一项荟萃分析]

[Genetic polymorphisms of ADH1B and ALDH-2 associated with risk of esophageal cancer: a meta-analysis].

作者信息

Duan Fujiao, Song Chunhua, Cui Shuli, Wang Longzhi, Zhen Qian, Qu Honghong, Wang Peng, Wang Kaijuan, Zhang Jianying, Dai Liping

机构信息

College of Public Health, Zhengzhou University, Zhengzhou 450001, China.

出版信息

Wei Sheng Yan Jiu. 2012 Sep;41(5):723-9.

PMID:23213683

Abstract

OBJECTIVE

To investigate the association of genetic polymorphisms of alcohol dehydrogenase-1B (ADH1B) and aldehyde dehydrogenase-2 (ALDH-2) with risk of esophageal cancer (EC) in China.

METHODS

A comprehensive search of the database was performed to identify all case-control studies of ADH1B and ALDH-2 polymorphisms associated with esophageal cancer and their interactions with alcohol drinking. Meta-analysis was carried out for calculation of pooled OR value and its corresponding 95% CI.

RESULTS

The ADH1B * 1 and ALDH-2 * 2 allele were found to be associated to increased risk of EC, with odds ratios (OR) being 1. 24 (95% CI 1.10-1.41) and 3.05 (95% CI 1.94-4.77) for the ADH1B * 1/* 2 and ADH1B * 1/1, and 1.6 (95% CI 1.01-2.03) and 0.77 (95% CI 0.28-2.09) for the ALDH-2 * 1/ 2 and ALDH-2 * 2/* 2 respectively. When compared with the ADH1B * 2/* 2 genotype in drinkers, the ADH1B * 1/* 2 + * 2/* 2 can increase risk of EC (OR = 3.13, 95% CI 2.17-4.51). ALDH-2 * 1/* 2 + * 2/* 2 showed an increased risk to EC among drinks compared with the ALDH-2 * 1/* 1 genotype (OR = 4.12, 95% CI 1.98-8.56).

CONCLUSION

ADH1B * 1 and ALDH-2 * 2 allele can increase the risk of EC in china, which can be modified by alcohol consumption.

摘要

目的

探讨乙醇脱氢酶-1B（ADH1B）和乙醛脱氢酶-2（ALDH-2）基因多态性与中国食管癌（EC）风险的关联。

方法

全面检索数据库，以识别所有关于ADH1B和ALDH-2多态性与食管癌及其与饮酒相互作用的病例对照研究。进行荟萃分析以计算合并OR值及其相应的95%置信区间。

结果

发现ADH1B *1和ALDH-2 *2等位基因与EC风险增加相关，ADH1B *1/*2和ADH1B *1/*1的优势比（OR）分别为1.24（95%CI 1.10 - 1.41）和3.05（95%CI 1.94 - 4.77），ALDH-2 *1/*2和ALDH-2 *2/*2的OR分别为1.6（95%CI 1.01 - 2.03）和0.77（95%CI 0.28 - 2.09）。与饮酒者中的ADH1B *2/*2基因型相比，ADH1B *1/*2 + *2/*2可增加EC风险（OR = 3.13，95%CI 2.17 - 4.51）。与ALDH-2 *1/*1基因型相比，ALDH-2 *1/*2 + *2/*2在饮酒者中显示出EC风险增加（OR = 4.12，95%CI 1.98 - 8.56）。