Henrichs H R
Diabetes-Zentrum, Christliches Krankenhaus, Quakenbrück, Bundesrepublik Deutschland.
Wien Klin Wochenschr Suppl. 1990;180:64-9; discussion 78-81.
The determination of fructosamine in serum is an accepted tool for the metabolic monitoring of diabetic patients. It provides an estimation of the glycemia state during the preceding 10 to 20 days. The turn-over of serum proteins is in general faster than that of hemoglobin. Therefore, fructosamine is faster responding than HbA1c to recompensation or fluctuations in glycemic control as observed in labile metabolic situations. On the other hand, under conditions of stable metabolic control fructosamine values correlate closely to HbA1c. The relation between the two parameters can be visualized in a nomogram of HbA1c, fructosamine and glucose or be expressed by a quotient (Glyc-Q = Fructosamine*2.2/HbA1c). A deviation from the stable metabolic situation (Glyc-Q = 100) reflects a trend in the recent development of glycemia: a Glyc-Q of greater than 120 is obtained in the state of decompensation, whereas in recompensation the Glyc-Q decreases significantly to values below 80. We propose to use the Glyc-Q in situations where a fast assessment of the glycemic state or an estimation of the development of glycemia within short intervals of observation are required.
血清果糖胺的测定是糖尿病患者代谢监测中一种公认的工具。它能估计前10至20天的血糖状态。血清蛋白的周转通常比血红蛋白快。因此，在不稳定的代谢情况下，果糖胺对血糖控制的重新补偿或波动的反应比糖化血红蛋白（HbA1c）更快。另一方面，在稳定的代谢控制条件下，果糖胺值与HbA1c密切相关。这两个参数之间的关系可以在HbA1c、果糖胺和葡萄糖的列线图中直观呈现，或者用一个商数（糖化商数Glyc-Q = 果糖胺×2.2/HbA1c）来表示。与稳定代谢情况（Glyc-Q = 100）的偏差反映了近期血糖发展的趋势：失代偿状态下糖化商数大于120，而在重新补偿时，糖化商数显著下降至80以下。我们建议在需要快速评估血糖状态或在短时间观察间隔内估计血糖发展情况时使用糖化商数。
