Frisch L E, Parmar H, Buckley L D, Chalem S A
Student Health Service, Southern Illinois University, Carbondale.
Acta Cytol. 1990 Mar-Apr;34(2):133-5.
Of 3,308 cervical cytologies performed at a university health service between September 1986 and September 1987, 371 were reported as showing inflammatory epithelial changes (IECs). Colposcopy was offered to all patients with this diagnosis and was actually performed on 200 (54%). Of these women, 44 had an atypical transformation zone; of the 33 who were biopsied, 23 had histologic diagnoses ranging from human papillomavirus (HPV) infection (4 cases) to grade III cervical intraepithelial neoplasia (CIN; 4 cases). Most biopsies showed CIN I. In our clinic, the 95% confidence limits for the histologic diagnosis of HPV or CIN in women with a cytologic diagnosis of IEC are 8.5% to 23.5%. Colposcopic examination of women with IEC may be able to detect patients with CIN who are missed by standard cytologic screening. Concerns about a potential bias from false-positive histology reports must be resolved before such an approach can be recommended.
1986年9月至1987年9月期间，在一所大学健康服务中心进行的3308例宫颈细胞学检查中，有371例报告显示有炎症性上皮改变（IECs）。对所有诊断为此病的患者都提供了阴道镜检查，实际进行检查的有200例（54%）。在这些女性中，44例有非典型转化区；在接受活检的33例中，23例的组织学诊断范围从人乳头瘤病毒（HPV）感染（4例）到III级宫颈上皮内瘤变（CIN；4例）。大多数活检显示为CIN I。在我们的诊所，细胞学诊断为IEC的女性中HPV或CIN组织学诊断的95%置信区间为8.5%至23.5%。对IEC女性进行阴道镜检查可能能够检测出标准细胞学筛查遗漏的CIN患者。在推荐这种方法之前，必须解决对假阳性组织学报告潜在偏差的担忧。
