Frisch L E, Buckley L D, Chalem S A
Student Health Service, Southern Illinois University, Carbondale.
Acta Cytol. 1990 Mar-Apr;34(2):129-32.
To assess the relationship between inflammatory epithelial changes (IECs) and cervicovaginal infection, 249 women with cytologic diagnoses of IEC were studied. The findings showed a Chlamydia infection in 15.7% of the cases, Monilia in 38.1%, Trichomonas in 1.6% and a lateral vaginal wall pH of greater than 5.5 in 29.7%. These results were compared with those for 211 controls drawn from the same population; women with abnormal cytologic reports were excluded from the control group. The controls had a prevalence of yeast and trichomoniasis no different from that of the IEC group. In contrast, the prevalence of chlamydial infection (7.6%) and pH greater than 5.5 (10.7%) were significantly lower in the controls than in the IEC cases. Chlamydia was found in 30.2% of 43 women with an atypical transformation zone, equally distributed between women whose biopsies were normal and those whose biopsies showed cervical intraepithelial neoplasia. The traditional guidelines of treating cases with cytologic diagnoses of IEC prior to obtaining a repeat smear may need reevaluation in the light of these findings.
为评估炎症性上皮改变（IECs）与宫颈阴道感染之间的关系，对249例经细胞学诊断为IEC的女性进行了研究。结果显示，15.7%的病例存在衣原体感染，38.1%存在念珠菌感染，1.6%存在滴虫感染，29.7%的阴道侧壁pH值大于5.5。将这些结果与从同一人群中选取的211名对照者的结果进行比较；异常细胞学报告的女性被排除在对照组之外。对照组中酵母菌和滴虫病的患病率与IEC组无差异。相比之下，对照组中衣原体感染的患病率（7.6%）和pH值大于5.5的患病率（10.7%）显著低于IEC病例组。在43例非典型转化区的女性中，30.2%发现了衣原体，在活检正常的女性和活检显示宫颈上皮内瘤变的女性中分布均匀。鉴于这些发现，在重复涂片检查之前对经细胞学诊断为IEC的病例进行治疗的传统指南可能需要重新评估。
