头孢他啶的正式合成。

Formal synthesis of cephalotaxine.

机构信息

State Key Laboratory Breeding Base-Hebei Province Key Laboratory of Molecular Chemistry for Drug, College of Chemical & Pharmaceutical Engineering, Hebei University of Science & Technology, Shijiazhuang, 050018, China.

出版信息

J Org Chem. 2013 Jan 18;78(2):786-90. doi: 10.1021/jo302608a. Epub 2012 Dec 17.

DOI:10.1021/jo302608a

PMID:23214930

Abstract

A formal synthesis of cephalotaxine, the parent member of the Cephalotaxus alkaloids, was achieved. It features a practical four-step assembly of the benzazepine-bearing pentacyclic ring system through two alkylation reactions, acidic hydrolysis, and aldolization.

摘要

实现了具有生物活性的三尖杉碱（ Cephalotaxus alkaloids 的母体成员）的全合成。该方法通过两步烷基化反应、酸性水解和羟醛缩合反应，以实用的四步反应构建了含苯并氮杂卓的五环骨架。