Department of Epidemiology, Biostatistics and HTA, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
Paediatr Perinat Epidemiol. 2013 Jan;27(1):34-43. doi: 10.1111/ppe.12023.
To optimise the health of pregnant women and their children by evidence-based primary and secondary prevention, more scientific knowledge is needed. To overcome the methodological limitations of many studies on pregnancy and child health, which often use a retrospective design, we established the PRIDE (PRegnancy and Infant DEvelopment) Study.
The PRIDE Study is a large prospective cohort study that aims at including 150 000-200 000 women in early pregnancy to study a broad range of research questions pertaining to pregnancy complications, maternal and child health, and adverse developmental effects in offspring. Women are invited to participate by their prenatal care provider before or at their first prenatal care visit and are asked to fill out web-based questionnaires in gestational weeks 8-10, 17, and 34, as well as biannually throughout childhood. In addition, a food frequency questionnaire and a paternal questionnaire are administered and medical records are consulted. Multiple validation studies will be conducted and paper-and-pencil questionnaires are available for women who cannot or do not want to participate through the Internet. For subgroups of participants, blood and saliva samples for genetic and biochemical analyses are being collected. The pilot phase, which started in July 2011, showed a response rate of 47%. Recruitment will eventually cover all of the Netherlands.
We expect that this study, which will be the largest birth cohort in the world so far, will provide new insights in the aetiology of disorders and diseases that originate in pregnancy. The PRIDE Study is open for collaboration.
为了通过循证一级和二级预防来优化孕妇及其子女的健康，我们需要更多的科学知识。为了克服许多关于妊娠和儿童健康的研究中经常使用回顾性设计的方法学局限性，我们建立了 PRIDE（妊娠和婴儿发育）研究。
PRIDE 研究是一项大型前瞻性队列研究，旨在在早孕期间纳入 150000-200000 名妇女，以研究与妊娠并发症、母婴健康以及后代不良发育影响相关的广泛研究问题。妇女在第一次产前检查之前或在第一次产前检查时由其产前护理提供者邀请参加，并被要求在妊娠 8-10 周、17 周和 34 周填写基于网络的问卷，以及在整个儿童期每半年填写一次。此外，还将进行多次验证研究，并为无法或不愿通过互联网参与的妇女提供纸质问卷。对于部分参与者，将采集血液和唾液样本进行遗传和生化分析。该研究于 2011 年 7 月开始启动试点阶段，反应率为 47%。最终将覆盖荷兰所有地区。
我们预计，这项研究将成为迄今为止世界上最大的出生队列研究，将为起源于妊娠的疾病和障碍的病因提供新的见解。PRIDE 研究欢迎合作。
