Goswitz Visala C, Sawicki Z Peter
Westman, Champlin and Kelly, P.A. 900 Second Avenue South, Minneapolis, MN 55402 USA.
Recent Pat Endocr Metab Immune Drug Discov. 2013 Jan;7(1):1-10.
Despite decades of research, current cancer therapies extend survival but often do not actually cure the disease. Immune cell based therapy is described here that can eliminate tumor cells without the toxicity associated with chemotherapy or allogeneic bone marrow transplant (BMT). Allogeneic BMT has beneficial graft vs. tumor (GVT) effects but accompanied by the undesirable graft vs. host disease (GVHD). The mechanism described here relates to generating the Mirror Effect™ that elicits a host vs. tumor (HVT) effect along with a non-toxic host vs. graft (HVG) response. The HVT effect generated by inducing the Mirror Effect™ in a host is effective in cancer therapy, as well as other diseases. The patent strategy, employed for successful patent prosecution related to the elucidation of the Mirror Effect™, is also discussed.
尽管经过了数十年的研究，但目前的癌症治疗方法虽能延长生存期，却往往无法真正治愈疾病。本文介绍了一种基于免疫细胞的疗法，该疗法可以消除肿瘤细胞，且不存在与化疗或异基因骨髓移植（BMT）相关的毒性。异基因骨髓移植具有有益的移植物抗肿瘤（GVT）效应，但同时伴有不良的移植物抗宿主病（GVHD）。本文所描述的机制涉及产生“镜像效应™”，该效应可引发宿主抗肿瘤（HVT）效应以及无毒的宿主抗移植物（HVG）反应。在宿主中诱导“镜像效应™”所产生的HVT效应在癌症治疗以及其他疾病中均有效。本文还讨论了为成功进行与阐明“镜像效应™”相关的专利申请而采用的专利策略。
