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临床转化癌症治疗中的纳米颗粒

Nanoparticles in Clinical Translation for Cancer Therapy.

机构信息

Centre for NanoBioTechnology (CNBT), Vellore Institute of Technology, Vellore 632014, Tamil Nadu, India.

Department of Clinical Oncology, Queen Elizabeth Hospital, Kowloon, Hong Kong, China.

出版信息

Int J Mol Sci. 2022 Feb 1;23(3):1685. doi: 10.3390/ijms23031685.

DOI:10.3390/ijms23031685
PMID:35163607
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8835852/
Abstract

The advent of cancer therapeutics brought a paradigm shift from conventional therapy to precision medicine. The new therapeutic modalities accomplished through the properties of nanomaterials have extended their scope in cancer therapy beyond conventional drug delivery. Nanoparticles can be channeled in cancer therapy to encapsulate active pharmaceutical ingredients and deliver them to the tumor site in a more efficient manner. This review enumerates various types of nanoparticles that have entered clinical trials for cancer treatment. The obstacles in the journey of nanodrug from clinic to market are reviewed. Furthermore, the latest developments in using nanoparticles in cancer therapy are also highlighted.

摘要

癌症治疗药物的出现带来了从传统治疗到精准医学的范式转变。通过纳米材料的特性实现的新治疗方式已经将其在癌症治疗中的应用范围扩展到了传统药物输送之外。纳米粒子可以被引导用于癌症治疗，以封装活性药物成分，并以更有效的方式将其递送到肿瘤部位。本文综述了已进入癌症治疗临床试验的各种类型的纳米粒子。还回顾了纳米药物从临床到市场的旅程中的障碍。此外，还强调了纳米粒子在癌症治疗中的最新进展。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6911/8835852/3b194f19be43/ijms-23-01685-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6911/8835852/5110984a1e9f/ijms-23-01685-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6911/8835852/a827897df7fe/ijms-23-01685-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6911/8835852/fc2139ecaa42/ijms-23-01685-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6911/8835852/ff1b5327479d/ijms-23-01685-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6911/8835852/eb5e13ed8e86/ijms-23-01685-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6911/8835852/3b194f19be43/ijms-23-01685-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6911/8835852/5110984a1e9f/ijms-23-01685-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6911/8835852/a827897df7fe/ijms-23-01685-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6911/8835852/fc2139ecaa42/ijms-23-01685-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6911/8835852/ff1b5327479d/ijms-23-01685-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6911/8835852/eb5e13ed8e86/ijms-23-01685-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6911/8835852/3b194f19be43/ijms-23-01685-g006.jpg

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Nanoparticles in Clinical Translation for Cancer Therapy.

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本文引用的文献

[1]
Ultrasound-Enhanced Generation of Reactive Oxygen Species for MRI-Guided Tumor Therapy by the Fe@FeO-Based Peroxidase-Mimicking Nanozyme.

ACS Appl Bio Mater. 2020-1-21

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Int J Mol Sci. 2021-12-5

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Pharmaceutics. 2021-7-27

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Mechanism of Ca-Dependent Pro-Apoptotic Action of Selenium Nanoparticles, Mediated by Activation of Cx43 Hemichannels.

Biology (Basel). 2021-8-3

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