Ahmadi Nariman, Delprado Warick J, Brooks Andrew J, Brenner Phillip C, Coombes Graham M, Grant Alexander, Patel Manish I
Urological Cancer Outcomes Centre, Discipline of Surgery, The University of Sydney, Sydney, New South Wales, Australia.
ANZ J Surg. 2014 Jun;84(6):473-6. doi: 10.1111/ans.12015. Epub 2012 Dec 10.
The aim of this study was to determine the incidence and tumour characteristics of incidental prostatic cancer in Australian men with primary bladder cancer undergoing radical cystoprostatectomy (RCP).
Cystoprostatectomy specimens were reviewed for a 10-year period from a leading pathology centre in the state of New South Wales, Australia. Stamey classification was used to define significant prostate cancer.
One hundred twenty-nine patients underwent RCP, 50 (39%) had prostatic adenocarcinoma, of which 35 (70%) were clinically significant. Apical involvement was seen in 10 (20%) of which 8 (16%) were clinically significant. High-grade intraepithelial neoplasia was seen in 27 (21%) and urothelial carcinoma or extension of bladder tumour was seen in 15 (12%) and 10 (8%) respectively. Bladder carcinoma in situ (CIS) was strongly associated with presence of urethral disease (P = 0.008).
High rates of prostatic involvement with adenocarcinoma and as well as urothelial malignancy was detected in patients with primary bladder cancer undergoing cystoprostatectomy. Large proportions of prostate adenocarcinoma were clinically significant. Presence of bladder CIS was significantly associated with presence of prostatic urethral disease.
本研究旨在确定澳大利亚原发性膀胱癌患者接受根治性膀胱前列腺切除术（RCP）时偶然发现的前列腺癌的发病率及肿瘤特征。
对澳大利亚新南威尔士州一家领先病理中心10年间的膀胱前列腺切除标本进行回顾。采用Stamey分类法定义显著前列腺癌。
129例患者接受了RCP，50例（39%）患有前列腺腺癌，其中35例（70%）具有临床显著性。10例（20%）出现尖部受累，其中8例（16%）具有临床显著性。27例（21%）出现高级别上皮内瘤变，15例（12%）出现尿路上皮癌或膀胱肿瘤侵犯，10例（8%）出现膀胱原位癌（CIS）。膀胱原位癌（CIS）与尿道疾病的存在密切相关（P = 0.008）。
在接受膀胱前列腺切除术的原发性膀胱癌患者中，发现前列腺腺癌及尿路上皮恶性肿瘤的发生率较高。大部分前列腺腺癌具有临床显著性。膀胱CIS的存在与前列腺尿道疾病的存在显著相关。
