Department of Molecular Biosciences, School of Veterinary Medicine, University of California-Davis, Davis, CA 95616, USA.
Diabetes Obes Metab. 2013 Jul;15(7):607-12. doi: 10.1111/dom.12048. Epub 2013 Jan 21.
There is a pressing need for new effective therapeutic strategies for addressing the epidemic of type 2 diabetes. Leptin has been shown to reduce hyperglycaemia in rodent models of type 1 diabetes and has recently been shown to normalize fasting plasma glucose concentrations in a rodent model of polygenic obesity and type 2 diabetes. Overall, these findings suggest that leptin may be an effective therapeutic option for both type 1 and type 2 diabetes. However, short-term human clinical studies in overweight and obese patients with recently diagnosed type 2 diabetes have reported minimal efficacy of leptin administration to lower blood glucose levels. Herein, the role of leptin in the maintenance of glucose homeostasis and the potential use of leptin in the treatment of type 2 diabetes are discussed.
目前迫切需要新的有效治疗策略来应对 2 型糖尿病的流行。瘦素已被证明可降低 1 型糖尿病啮齿动物模型中的高血糖，最近还被证明可使多基因肥胖和 2 型糖尿病啮齿动物模型中的空腹血浆葡萄糖浓度正常化。总体而言，这些发现表明瘦素可能是 1 型和 2 型糖尿病的有效治疗选择。然而，在最近被诊断患有 2 型糖尿病的超重和肥胖患者的短期人体临床研究中，报告了瘦素给药降低血糖水平的效果极小。本文讨论了瘦素在维持葡萄糖稳态中的作用以及瘦素在治疗 2 型糖尿病中的潜在用途。
