Department of Exploratory Medicine for Nature, Life and Humans, Toho University School of Medicine, Chiba, Japan.
Department of Pathology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.
J Diabetes Investig. 2023 Sep;14(9):1015-1037. doi: 10.1111/jdi.14034. Epub 2023 Jul 3.
Diabetes mellitus is still expanding globally and is epidemic in developing countries. The combat of this plague has caused enormous economic and social burdens related to a lowered quality of life in people with diabetes. Despite recent significant improvements of life expectancy in patients with diabetes, there is still a need for efforts to elucidate the complexities and mechanisms of the disease processes to overcome this difficult disorder. To this end, the use of appropriate animal models in diabetes studies is invaluable for translation to humans and for the development of effective treatment. In this review, a variety of animal models of diabetes with spontaneous onset in particular will be introduced and discussed for their implication in diabetes research.
糖尿病在全球范围内仍在不断蔓延，在发展中国家更是呈流行趋势。这场与糖尿病的斗争给患者的生活质量带来了负面影响，同时也给社会带来了巨大的经济和社会负担。尽管近年来糖尿病患者的预期寿命有了显著提高，但仍需要努力阐明疾病过程的复杂性和机制，以克服这一难题。为此，在糖尿病研究中使用适当的动物模型对于向人类转化和开发有效的治疗方法非常有价值。在这篇综述中，将介绍和讨论各种具有自发性发病的糖尿病动物模型，讨论它们在糖尿病研究中的应用。
