Soldado Francisco, Benito-Castillo David, Fontecha Cesar G, Barber Ignasi, Marotta Mario, Haddad Sleiman, Menendez Mariano E, Mascarenhas Vasco V, Kozin Scott H
Vall Hebron Research Institute (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain.
J Brachial Plex Peripher Nerve Inj. 2012 Dec 6;7(1):9. doi: 10.1186/1749-7221-7-9.
Shoulder abnormalities are the major cause of morbidity in upper brachial plexus birth palsy (BPBP). We developed a rat model of upper trunk BPBP and compared our findings to previously reported animal models and to clinical findings in humans.
Forty-three 5-day-old newborn rats underwent selective upper trunk neurectomy of the right brachial plexus and were studied 3 to 20 weeks after surgery. The passive shoulder external rotation was measured and the shoulder joint was assessed bilaterally by a 7.2T MRI bilaterally.
We found a marked decrease in passive shoulder external rotation, associated with a severe subscapularis muscle atrophy and contracture. None however developed the typical pattern of glenohumeral dysplasia.
In contradiction with previous reports, our study shows that the rat model is not adequate for preclinical studies of shoulder dysplasia. However, it might serve as a useful model for studies analyzing shoulder contracture occurring after upper BPBP.
肩部异常是上臂丛神经产瘫（BPBP）发病的主要原因。我们建立了一种大鼠上干BPBP模型，并将我们的研究结果与先前报道的动物模型以及人类临床结果进行了比较。
对43只5日龄新生大鼠进行右侧臂丛神经选择性上干神经切除术，并在术后3至20周进行研究。测量被动肩部外旋，并通过7.2T MRI对双侧肩关节进行评估。
我们发现被动肩部外旋明显减少，伴有严重的肩胛下肌萎缩和挛缩。然而，没有一只出现典型的盂肱关节发育不良模式。
与先前的报道相反，我们的研究表明该大鼠模型不适用于肩部发育不良的临床前研究。然而，它可能是分析上臂BPBP后发生的肩部挛缩的有用模型。
