Division of Clinical Neurooncology, Department of Neurology, University of Bonn Medical Center, Bonn, Sigmund-Freud-Straße 25, 53127 Bonn, Germany.
Exp Hematol Oncol. 2012 Dec 5;1(1):37. doi: 10.1186/2162-3619-1-37.
Intravascular diffuse large B-cell lymphoma limited to the CNS (cIVL) is a very rare malignant disorder characterized by a selective accumulation of neoplastic lymphocytes (usually B cells) within the lumen of CNS blood vessels but not in the brain parenchyma. In the past, treatment of cIVL with anthracycline-based regimens was unsatisfactory with very short survival times. In the case of cIVL presented here, high-dose methotrexate-based polychemotherapy according to the Bonn protocol plus rituximab therapy was successful and led to a complete clinical and MRI remission which is ongoing 29 months after diagnosis.
中枢神经系统血管内弥漫性大 B 细胞淋巴瘤（cIVL）是一种非常罕见的恶性疾病，其特征是肿瘤性淋巴细胞（通常为 B 细胞）选择性地在中枢神经系统血管管腔内积聚，但不在脑实质中。过去，采用蒽环类药物为基础的方案治疗 cIVL 的效果并不令人满意，患者的生存时间非常短。在本例中，采用波恩方案的大剂量甲氨蝶呤为基础的联合化疗加上利妥昔单抗治疗获得成功，并导致完全的临床和 MRI 缓解，诊断后 29 个月仍在持续。
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