Gene Expression Analysis Laboratory, Cancer Research UK London Research Institute, 44 Lincoln's Inn Fields, London WC2A 3LY, UK.
Cell Metab. 2012 Dec 5;16(6):687-8. doi: 10.1016/j.cmet.2012.11.010.
Glycogen metabolism operates as an alternative energy source, enabling cell growth under conditions of metabolic stress. Favaro et al. (2012) now demonstrate that in hypoxic cancer cells, depletion of liver glycogen phosphorylase causes glycogen accumulation, leading to oxidative stress, induction of senescence, and impaired tumor growth in vivo.
糖原代谢作为一种替代能源，使细胞能够在代谢应激条件下生长。Favaro 等人（2012 年）现在证明，在缺氧的癌细胞中，肝糖原磷酸化酶的耗竭会导致糖原积累，从而导致氧化应激、衰老诱导和体内肿瘤生长受损。
