Division of Vascular Surgery, Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA.
Semin Nephrol. 2012 Nov;32(6):582-91. doi: 10.1016/j.semnephrol.2012.10.010.
Dialysis grafts have provided reliable access for millions of patients in need of renal replacement therapy. However, regardless of the material used for artificial dialysis grafts their mean patency remains generally poor and infection rates are greater than native arteriovenous fistulas. The need for superior alternatives to conventional synthetic materials used for vascular access has been an area of investigation for more than 25 years and recently there has been a great deal of progress in the field of tissue-engineered vascular grafts. Many of these technologies are either commercially available or are now entering early phases of clinical trials. This review briefly covers the history, potential advantages, and disadvantages of these technologies, which are likely to create an impact in the field of vascular access surgery.
透析移植物为数百万需要肾脏替代治疗的患者提供了可靠的通路。然而，无论用于人工透析移植物的材料如何，其平均通畅率普遍较差，感染率高于天然动静脉瘘。超过 25 年来，人们一直在研究替代传统用于血管通路的合成材料的更好方法，最近在组织工程血管移植物领域取得了很大进展。其中许多技术已经商业化，或者现在已经进入临床试验的早期阶段。本文简要回顾了这些技术的历史、潜在优势和劣势，这些技术可能会对血管通路手术领域产生影响。
