State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Dingxi Road, Shanghai 200050, People's Republic of China.
Regen Biomater. 2014 Nov;1(1):81-9. doi: 10.1093/rb/rbu009. Epub 2014 Oct 20.
Heart valve and blood vessel replacement using artificial prostheses is an effective strategy for the treatment of cardiovascular disease at terminal stage. Natural extracellular matrix (ECM)-derived materials (decellularized allogeneic or xenogenic tissues) have received extensive attention as the cardiovascular scaffold. However, the bioprosthetic grafts usually far less durable and undergo calcification and progressive structural deterioration. Glutaraldehyde (GA) is a commonly used crosslinking agent for improving biocompatibility and durability of the natural scaffold materials. However, the nature ECM and GA-crosslinked materials may result in calcification and eventually lead to the transplant failure. Therefore, studies have been conducted to explore new crosslinking agents. In this review, we mainly focused on research progress of ECM-derived cardiovascular scaffolds and their crosslinking strategies.
采用人工假体进行心脏瓣膜和血管置换是治疗终末期心血管疾病的有效策略。天然细胞外基质（ECM）衍生材料（去细胞化同种异体或异种组织）作为心血管支架受到广泛关注。然而，生物假体移植物通常耐用性较差，会发生钙化和进行性结构恶化。戊二醛（GA）是一种常用的交联剂，用于提高天然支架材料的生物相容性和耐用性。然而，天然 ECM 和 GA 交联材料可能导致钙化，并最终导致移植失败。因此，人们已经开展了研究来探索新的交联剂。在本综述中，我们主要关注 ECM 衍生的心血管支架及其交联策略的研究进展。
