金童玉女法则判定 ESC 双能性
Utf1: Goldilocks for ESC bivalency.
机构信息
Department of Cell Biology and Human Anatomy, University of California Davis School of Medicine, Sacramento, CA 95817, USA.
出版信息
Cell Stem Cell. 2012 Dec 7;11(6):732-4. doi: 10.1016/j.stem.2012.11.012.
Abstract
Recently in Cell, Jia et al. (2012) reported novel Utf1-controlled mechanisms of maintaining pluripotency and self-renewal in embryonic stem cells (ESCs). Utf1 buffers bivalent gene expression by competitive binding with polycomb repressive complex 2 and initiation of mRNA degradation.
摘要
最近，在《细胞》杂志上，Jia 等人（2012 年）报道了新型 Utf1 控制胚胎干细胞（ESCs）多能性和自我更新的机制。Utf1 通过与多梳抑制复合物 2 的竞争性结合和 mRNA 降解的起始，缓冲双价基因的表达。
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本文引用的文献
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