Howard Hughes Medical Institute and Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA.
Nat Rev Genet. 2011 Jan;12(1):7-18. doi: 10.1038/nrg2905. Epub 2010 Nov 30.
A succession of technological advances over the past decade have enabled researchers to chart maps of histone modifications and related chromatin structures with increasing accuracy, comprehensiveness and throughput. The resulting data sets highlight the interplay between chromatin and genome function, dynamic variations in chromatin structure across cellular conditions, and emerging roles for large-scale domains and higher-ordered chromatin organization. Here we review a selection of recent studies that have probed histone modifications and successive layers of chromatin structure in mammalian genomes, the patterns that have been identified and future directions for research.
过去十年中的一系列技术进步使得研究人员能够以越来越高的准确性、全面性和通量绘制组蛋白修饰和相关染色质结构图谱。所得数据集突出了染色质与基因组功能之间的相互作用、细胞状态下染色质结构的动态变化以及大规模域和更高阶染色质组织的新兴作用。在这里，我们回顾了一些最近的研究，这些研究探讨了哺乳动物基因组中的组蛋白修饰和连续的染色质结构层，以及已经确定的模式和未来的研究方向。
