光动力疗法治疗口腔扁平苔藓。
Photodynamic treatment of oral lichen planus.
机构信息
Institute of Clinical Dentistry, Faculty of Dentistry, University of Oslo, Oslo, Norway.
出版信息
Oral Surg Oral Med Oral Pathol Oral Radiol. 2013 Jan;115(1):62-70. doi: 10.1016/j.oooo.2012.08.448.
OBJECTIVES
The aim of this study was to examine the clinical behavior and response to topical methyl 5-aminolevulinate (MAL) photodynamic therapy (PDT) of oral lichen planus and to describe the buildup and biodistribution of photoactive porphyrins in normal and lichen planus-affected oral mucosa after MAL application.
STUDY DESIGN
The difference in clinical expression in 14 patients with buccal oral lichen planus was compared before and after treatment. MAL-induced photoactive porphyrins were monitored using noninvasive in situ fluorescence measurements. Microfluorometry was used to study the biodistribution.
RESULTS
The absorption and conversion of protoporphyrin IX (PpIX) in epithelial and subepithelial T cells was demonstrated in histologic sections. As a result of 1 treatment session, there was a significant improvement of oral lichen planus after 6 months (P = 0.02) and during a 4-year follow-up period.
CONCLUSIONS
MAL is absorbed and converted to PpIX in T cells. Oral lichen planus treated with MAL-PDT showed lasting improvement after a single treatment.
目的
本研究旨在观察口腔扁平苔藓患者接受局部 5-氨基酮戊酸（MAL）光动力疗法（PDT）的临床行为和反应，并描述 MAL 应用后正常和扁平苔藓受累口腔黏膜中光活性卟啉的蓄积和分布。
设计
比较 14 例颊部口腔扁平苔藓患者治疗前后的临床表现差异。采用非侵入性原位荧光测量法监测 MAL 诱导的光活性卟啉。采用显微荧光光度法研究其分布。
结果
在组织学切片中证明了上皮细胞和上皮下 T 细胞中原卟啉 IX（PpIX）的吸收和转化。经过 1 次治疗后，6 个月时（P = 0.02）和 4 年随访期间，口腔扁平苔藓有显著改善。
结论
MAL 在 T 细胞中被吸收并转化为 PpIX。MAL-PDT 治疗的口腔扁平苔藓在单次治疗后显示出持久的改善。
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