Institute of Clinical Dentistry, Faculty of Dentistry, University of Oslo, Oslo, Norway.
Oral Surg Oral Med Oral Pathol Oral Radiol. 2013 Jan;115(1):62-70. doi: 10.1016/j.oooo.2012.08.448.
The aim of this study was to examine the clinical behavior and response to topical methyl 5-aminolevulinate (MAL) photodynamic therapy (PDT) of oral lichen planus and to describe the buildup and biodistribution of photoactive porphyrins in normal and lichen planus-affected oral mucosa after MAL application.
The difference in clinical expression in 14 patients with buccal oral lichen planus was compared before and after treatment. MAL-induced photoactive porphyrins were monitored using noninvasive in situ fluorescence measurements. Microfluorometry was used to study the biodistribution.
The absorption and conversion of protoporphyrin IX (PpIX) in epithelial and subepithelial T cells was demonstrated in histologic sections. As a result of 1 treatment session, there was a significant improvement of oral lichen planus after 6 months (P = 0.02) and during a 4-year follow-up period.
MAL is absorbed and converted to PpIX in T cells. Oral lichen planus treated with MAL-PDT showed lasting improvement after a single treatment.
本研究旨在观察口腔扁平苔藓患者接受局部 5-氨基酮戊酸（MAL）光动力疗法（PDT）的临床行为和反应，并描述 MAL 应用后正常和扁平苔藓受累口腔黏膜中光活性卟啉的蓄积和分布。
比较 14 例颊部口腔扁平苔藓患者治疗前后的临床表现差异。采用非侵入性原位荧光测量法监测 MAL 诱导的光活性卟啉。采用显微荧光光度法研究其分布。
在组织学切片中证明了上皮细胞和上皮下 T 细胞中原卟啉 IX（PpIX）的吸收和转化。经过 1 次治疗后，6 个月时（P = 0.02）和 4 年随访期间，口腔扁平苔藓有显著改善。
MAL 在 T 细胞中被吸收并转化为 PpIX。MAL-PDT 治疗的口腔扁平苔藓在单次治疗后显示出持久的改善。
