清理：ER 相关降解来拯救。
Cleaning up: ER-associated degradation to the rescue.
机构信息
Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA.
出版信息
Cell. 2012 Dec 7;151(6):1163-7. doi: 10.1016/j.cell.2012.11.012.
Abstract
All cellular proteins are subject to quality control "decisions," which help to prevent or delay a myriad of diseases. Quality control within the secretory pathway creates a special challenge, as aberrant polypeptides are recognized and returned to the cytoplasm for proteasomal degradation. This process is termed endoplasmic-reticulum (ER)-associated degradation (ERAD).
摘要
所有的细胞蛋白都受到质量控制“决策”的影响，这些决策有助于预防或延缓多种疾病的发生。在分泌途径中进行质量控制会带来特殊的挑战，因为异常的多肽会被识别并返回细胞质进行蛋白酶体降解。这个过程被称为内质网（ER）相关降解（ERAD）。
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