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苯达莫司汀诱发的“鞭毛虫皮炎”。

Bendamustine-induced "flagellate dermatitis".

作者信息

Mahmoud Bassel H, Eide Melody J

机构信息

Department of Dermatology, Henry Ford Hospital, Detroit, Michigan, USA.

出版信息

Dermatol Online J. 2012 Nov 15;18(11):12.

PMID:23217953
Abstract

BACKGROUND

The term "flagellate erythema" after bleomycin therapy was described as bleomycin-induced linear hyperpigmentation. Since then, this pattern has not been related to any other chemotherapeutic regimen.

OBSERVATION

We report a rare patient with chronic lymphocytic leukemia who developed "flagellate dermatitis" induced by bendamustine.

CONCLUSION

Chemotherapy induced "Flagellate Dermatitis" is a rare finding reported only after bleomycin therapy. We describe the first case with this characteristic eruption pattern after administration of bendamustine.

摘要

背景

博来霉素治疗后的“鞭状红斑”这一术语被描述为博来霉素诱导的线性色素沉着。从那时起,这种皮疹模式与任何其他化疗方案均无关联。

观察

我们报告了1例罕见的慢性淋巴细胞白血病患者,其发生了由苯达莫司汀诱导的“鞭状皮炎”。

结论

化疗诱导的“鞭状皮炎”是一种仅在博来霉素治疗后才被报道的罕见发现。我们描述了首例在使用苯达莫司汀后出现这种特征性皮疹模式的病例。

相似文献

1
Bendamustine-induced "flagellate dermatitis".苯达莫司汀诱发的“鞭毛虫皮炎”。
Dermatol Online J. 2012 Nov 15;18(11):12.
2
[Toxicodermia by bendamustine: development of a desensization protocol].[苯达莫司汀所致中毒性皮肤病:脱敏方案的制定]
Farm Hosp. 2013 Sep-Oct;37(5):421-3. doi: 10.7399/FH.2013.37.5.703.
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Short communication: bendamustine-related hemolytic anemia in chronic lymphocytic leukemia.短篇交流:慢性淋巴细胞白血病中苯达莫司汀相关性溶血性贫血。
Cancer Chemother Pharmacol. 2013 Sep;72(3):709-13. doi: 10.1007/s00280-013-2243-5. Epub 2013 Aug 2.
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Therapy-related acute myeloid leukemia in a patient with chronic lymphocytic leukemia treated with rituximab-bendamustine.一名接受利妥昔单抗-苯达莫司汀治疗的慢性淋巴细胞白血病患者发生的治疗相关急性髓系白血病
Ann Hematol. 2014 Apr;93(4):699-702. doi: 10.1007/s00277-013-1844-8. Epub 2013 Aug 2.
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Preliminary experience with the use of bendamustine: a peculiar skin rash as the commonest side effect.苯达莫司汀使用的初步经验:一种特殊皮疹为最常见的副作用。
Hematol Oncol Stem Cell Ther. 2011;4(4):157-60. doi: 10.5144/1658-3876.2011.157.
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Clinical experience of bendamustine treatment for non-Hodgkin lymphoma and chronic lymphocytic leukemia in Spain.西班牙使用苯达莫司汀治疗非霍奇金淋巴瘤和慢性淋巴细胞白血病的临床经验。
Leuk Res. 2012 Jun;36(6):709-14. doi: 10.1016/j.leukres.2011.10.024. Epub 2011 Dec 7.
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Severe cutaneous interface drug eruption associated with bendamustine.与苯达莫司汀相关的严重皮肤界面药物疹
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Bendamustine compared with chlorambucil in previously untreated patients with chronic lymphocytic leukaemia: updated results of a randomized phase III trial.苯达莫司汀与苯丁酸氮芥治疗初治慢性淋巴细胞白血病患者的比较:一项随机 III 期试验的更新结果。
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Appropriate use of bendamustine in first-line therapy of chronic lymphocytic leukemia. Recommendations from SIE, SIES, GITMO Group.苯达莫司汀在慢性淋巴细胞白血病一线治疗中的合理应用。来自 SIE、SIES、GITMO 小组的建议。
Leuk Res. 2014 Nov;38(11):1269-77. doi: 10.1016/j.leukres.2014.06.017. Epub 2014 Jul 7.
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Bleomycin-induced flagellate dermatitis.博来霉素诱发的鞭毛虫皮炎。
Int J Dermatol. 2007 Nov;46 Suppl 3:3-5. doi: 10.1111/j.1365-4632.2007.03499.x.

引用本文的文献

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Front Med (Lausanne). 2025 Aug 5;12:1610203. doi: 10.3389/fmed.2025.1610203. eCollection 2025.
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Appearance of a "Whip-Like" Rash in a Young Male Undergoing Therapy for Testicular Embryonal Carcinoma.一名接受睾丸胚胎癌治疗的年轻男性出现“鞭状”皮疹。
Cureus. 2022 Dec 28;14(12):e33065. doi: 10.7759/cureus.33065. eCollection 2022 Dec.
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A closer look at chemotherapy-induced flagellate dermatitis.
深入探究化疗引起的鞭毛虫性皮炎。
Skin Health Dis. 2022 Jan 19;2(1):e92. doi: 10.1002/ski2.92. eCollection 2022 Mar.
4
Clinical Approach to Linear Hyperpigmentation: A Review Article.线性色素沉着的临床处理:一篇综述文章
Clin Cosmet Investig Dermatol. 2021 Jan 8;14:23-35. doi: 10.2147/CCID.S280819. eCollection 2021.
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Unusual and Interesting Adverse Cutaneous Drug Reactions.罕见且有趣的皮肤药物不良反应
Indian J Dermatol. 2018 Mar-Apr;63(2):107-116. doi: 10.4103/ijd.IJD_584_17.
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Flagellate Rash: An Unusual Complication of Bleomycin Therapy - A Case Report with Brief Review of Literature.鞭毛虫疹:博来霉素治疗的一种罕见并发症——病例报告及文献综述
Indian J Med Paediatr Oncol. 2017 Oct-Dec;38(4):548-551. doi: 10.4103/ijmpo.ijmpo_147_16.
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Trastuzumab-Associated Flagellate Erythema: Report in a Woman with Metastatic Breast Cancer and Review of Antineoplastic Therapy-Induced Flagellate Dermatoses.曲妥珠单抗相关的鞭毛虫样红斑:1例转移性乳腺癌女性患者的报告及抗肿瘤治疗引起的鞭毛虫样皮肤病综述
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Flagellate dermatitis after consumption of Shiitake mushrooms.食用香菇后出现鞭毛虫性皮炎。
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