Chen Xinrong, Zheng Chuangjie, Wang Ke, Zhai Linzhu
The First Clinical Medical College of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, China.
Cancer Center, The First Affiliated Hospital of Guangzhou University of Chinese, Guangzhou, Guangdong, China.
Front Med (Lausanne). 2025 Aug 5;12:1610203. doi: 10.3389/fmed.2025.1610203. eCollection 2025.
We present a detailed report of a case of flagellar-like skin pigmentation observed in a 15-year-old female patient diagnosed with ovarian yolk sac tumor following administration of a chemotherapy regimen containing bleomycin. After three cycles of chemotherapy, the patient exhibited characteristic painless, non-pruritic linear hyperpigmentation on her trunk and back. This case underscores the significance of paying attention to bleomycin-associated dermal toxicity, emphasizing the need for its early detection and management to alleviate the patient's psychological and physical distress. Our research indicates that additional studies are necessary to comprehensively understand the underlying mechanisms of flagellar-like skin pigmentation and to identify effective prevention and treatment approaches.
我们报告了一例15岁女性患者的详细病例，该患者在接受含博来霉素的化疗方案后被诊断为卵巢卵黄囊瘤，出现了鞭毛样皮肤色素沉着。化疗三个周期后，患者躯干和背部出现了典型的无痛、非瘙痒性线性色素沉着。该病例强调了关注博来霉素相关皮肤毒性的重要性，强调了早期发现和处理以减轻患者心理和身体痛苦的必要性。我们的研究表明，有必要进行更多研究以全面了解鞭毛样皮肤色素沉着的潜在机制，并确定有效的预防和治疗方法。
