Kolodzik J M, Eilers M A, Angelos M G
Department of Emergency Medicine, Wright State University, School of Medicine, Dayton, Ohio 45401-0927.
Ann Emerg Med. 1990 Apr;19(4):378-81. doi: 10.1016/s0196-0644(05)82339-x.
We present the case of a 17-year-old girl who ingested 24 to 36 g fenoprofen as a suicidal gesture. She presented with coma, hypotension, metabolic acidosis, and respiratory depression within four hours of ingestion. The most common adverse effects of the nonsteroidal anti-inflammatory drugs occur in both therapeutic and toxic doses and include gastrointestinal upset, blood dyscrasias, and analgesic nephropathy. The propionic acid derivatives of nonsteroidal anti-inflammatory drugs, including fenoprofen and ibuprofen, are rarely associated with severe toxic effects. This is the first report of pure fenoprofen overdose presenting as coma and metabolic acidosis.
