Department of Surgery, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, 100 Taiwan, ROC.
Carbohydr Polym. 2013 Jan 30;92(1):591-7. doi: 10.1016/j.carbpol.2012.09.012. Epub 2012 Sep 16.
The cardiac repair of myocardial infarction (MI) hearts of rats using chitosan-hyaluronan/silk fibroin (chitosan-HYA/SF) cardiac patches was examined after eight weeks of implantation. Rats with implantations of chitosan-HYA/SF patches (CHS group) significantly (P<0.05) reduced the dilation of the inner diameter of left ventricle (LV) (4.27 ± 0.29 mm), increased wall thickness of LV (1.5 ± 0.13 mm) and improved the fractional shortening of LV of hearts (LVFS) (42.8 ± 2.4%) compared with those values of LVs of rats without implants (MI group) (e.g., 5.92 ± 0.39 mm, 1.2 ± 0.06 mm and 31.5±1.4%, respectively). Moreover, blood vessel-like structures in MI regions of LVs in the CHS group were widely distributed while none was found in the MI group. The CHS group significantly improved the secretion of paracrine factors, such as VEGF in the MI regions of LVs (P<0.05, n=4), relative to that in the MI group. In conclusion, chitosan-HYA/SF cardiac patches are promising biomaterials for the cardiac repair of MI rat hearts.
将壳聚糖-透明质酸/丝素（chitosan-HYA/SF）心脏贴片用于大鼠心肌梗死（MI）心脏的心脏修复，在植入 8 周后进行了检查。植入壳聚糖-HYA/SF 贴片的大鼠（CHS 组）与未植入的大鼠（MI 组）相比，左心室（LV）内径扩张明显减少（4.27±0.29mm），LV 壁厚度增加（1.5±0.13mm），LV 的缩短分数（LVFS）改善（42.8±2.4%）。此外，CHS 组 LV 的 MI 区域中广泛分布着类似血管的结构，而 MI 组则没有。与 MI 组相比，CHS 组在 LV 的 MI 区域中显著增加了旁分泌因子（如 VEGF）的分泌（P<0.05，n=4）。总之，壳聚糖-HYA/SF 心脏贴片是修复 MI 大鼠心脏的有前途的生物材料。
