Institute of Textiles and Clothing and Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong, China.
Carbohydr Polym. 2013 Jan 30;92(1):877-80. doi: 10.1016/j.carbpol.2012.09.080. Epub 2012 Oct 13.
In this study, a novel green microencapsulation system was used to develop Phyllanthus urinaria (PU) extract containing microcapsules. Agar was used with gelatin as the wall matrix materials of microcapsules to prevent the use of toxic crosslinker formaldehyde. Microencapsulated PU extract was developed to improve the potential antifungal activities of PU water extracts. The active components and surface morphology of PU extract containing microcapsules were analyzed by liquid chromatography/mass spectrometry and scanning electron microscopy, respectively. The in vitro release study demonstrated that approximately 80% of drug was released after 120 h. PU loaded microcapsules were shown to have a stronger anti-Aspergillus niger activity than the free drug.
在这项研究中，采用了一种新型的绿色微胶囊系统来开发含有叶下珠（PU）提取物的微胶囊。使用琼脂与明胶作为微胶囊的壁基质材料，以防止使用有毒的交联剂甲醛。开发微囊化的 PU 提取物是为了提高 PU 水提取物的潜在抗真菌活性。通过液相色谱/质谱联用和扫描电子显微镜分别分析了含有微胶囊的 PU 提取物的活性成分和表面形态。体外释放研究表明，大约 80%的药物在 120 小时后释放。负载 PU 的微胶囊显示出比游离药物更强的抗黑曲霉活性。
