Liu Yi-Hsiu, Liu Chang-Pan, Lee Chun-Ming
Department of Medicine, Keelung Hospital, Department of Health, Executive Yuan, Taiwan.
Division of Infectious Disease, Department of Medicine, Mackay Memorial Hospital, Taipei, Taiwan; Mackay Medicine, Nursing and Management College, Taipei, Taiwan; Taipei Medical University, Taipei, Taiwan; Microbiology Section, Department of Medical Research, Mackay Memorial Hospital, Taipei, Taiwan.
J Microbiol Immunol Infect. 2014 Apr;47(2):104-8. doi: 10.1016/j.jmii.2012.08.027. Epub 2012 Dec 3.
BACKGROUND/PURPOSE: Splenic abscesses are uncommon. This study aimed at assembling the demographics, clinical features, microbiologic etiologies, imaging, treatments, and outcomes of patients with splenic abscesses at a tertiary medical center in northern Taiwan.
The diagnosis of splenic abscess was made either by imaging studies associated with clinical symptoms and signs of infection, or by imaging studies associated with microbiological data or pathologic results. The clinical characteristics, isolated pathogens, and treatments diagnosed at a medical center in northern Taiwan between 2000 and 2011 were analyzed retrospectively.
Of 28 patients with splenic abscess, male patients accounted for 46% of the study population. The mean age of the patients at the time of presentation was 46.5 years (range 4 months to 85 years). Common presentations were fever (71.4%, 20 cases), abdominal pain (46.4%, 13 cases), cough or dyspnea (35.7%, 10 cases), splenomegaly (32.1%, 9 cases), and left-sided pleural effusion (32.1%, 9 cases). Leukocytosis was noted in 22 patients (78.5%). Gram-negative bacilli and Gram-positive cocci were cultivated from six patients (21%). No specific pathogen was predominant in patients with splenic abscesses. The overall mortality was 14.3%, while the mortality among the patients treated with antimicrobial therapy alone was 5.6%.
The survival rate was high in patients with splenic abscesses who received antimicrobial therapy alone. Percutaneous drainage can be used as an alternative choice for patients with severe co-morbidities or patients who are critically ill.
背景/目的:脾脓肿并不常见。本研究旨在汇总台湾北部一家三级医疗中心脾脓肿患者的人口统计学资料、临床特征、微生物病因、影像学表现、治疗方法及治疗结果。
脾脓肿的诊断依据与感染临床症状和体征相关的影像学检查,或与微生物学数据或病理结果相关的影像学检查。回顾性分析2000年至2011年期间在台湾北部一家医疗中心诊断的脾脓肿患者的临床特征、分离出的病原体及治疗情况。
28例脾脓肿患者中,男性占研究人群的46%。患者就诊时的平均年龄为46.5岁(范围4个月至85岁)。常见表现为发热(71.4%,20例)、腹痛(46.4%,13例)、咳嗽或呼吸困难(35.7%,10例)、脾肿大(32.1%,9例)和左侧胸腔积液(32.1%,9例)。22例患者(78.5%)出现白细胞增多。6例患者(21%)培养出革兰氏阴性杆菌和革兰氏阳性球菌。脾脓肿患者中无特定优势病原体。总体死亡率为14.3%,而仅接受抗菌治疗的患者死亡率为5.6%。
仅接受抗菌治疗的脾脓肿患者生存率较高。经皮引流可作为合并症严重或病情危重患者的替代选择。