McGill University Health Centre (Montreal General Hospital), 1650 Cedar Avenue, Montreal, Quebec, Canada H3G 1A4.
Best Pract Res Clin Rheumatol. 2012 Oct;26(5):695-704. doi: 10.1016/j.berh.2012.08.006.
Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterised by variable and unpredictable manifestations that can severely affect a person's physical and mental well-being, social life and ability to acquire and maintain gainful employment. Damage to vital organs may ensue as a result of the disease itself or as a consequence of treatment, and patients often consume substantial health-care resources and incur considerable health-care costs. Furthermore, SLE tends to affect women in young and middle adulthood, at a time in their lives when they are usually most actively engaged in the workforce, and can have important consequences with respect to acquiring and maintaining employment and advancing in one's career. A number of studies have attempted to assess the health-care costs (direct costs) associated with SLE, the effects of SLE on employment and the associated costs due to decreases in work productivity (indirect costs). In this article, we review a number of recent studies that have added to our current understanding of the economic burden of SLE.
系统性红斑狼疮（SLE）是一种全身性自身免疫性疾病，其表现具有多变性和不可预测性，可严重影响患者的身心健康、社会生活和获得并保持有酬就业的能力。由于疾病本身或治疗的结果，可能会导致重要器官受损，患者通常会消耗大量的医疗保健资源并产生相当大的医疗保健费用。此外，SLE 通常会影响处于青壮年的女性，此时她们通常正处于职业生涯中最活跃的阶段，这可能会对她们获得和保持工作以及职业发展产生重要影响。一些研究试图评估与 SLE 相关的医疗保健费用（直接成本）、SLE 对就业的影响以及因工作生产力下降而导致的相关费用（间接成本）。在本文中，我们回顾了一些最近的研究，这些研究增加了我们对 SLE 经济负担的现有认识。
