Department of Internal Medicine C, Rabin Medical Center, Hasharon Hospital, Petah-Tiqva, Israel.
Biomed Pharmacother. 2013 Feb;67(1):43-7. doi: 10.1016/j.biopha.2012.10.008. Epub 2012 Nov 15.
Resveratrol, a natural polyphenolic compound found mainly in grapes and their seeds, is gaining a widespread appreciation as a therapeutic adjuvant in a variety of diseases including cancer prevention. We examined the effect of resveratrol as a modulator of the immune dialog between peripheral blood mononuclear cells and those from two human colon carcinoma lines, expressed by a possible alteration of cytokine production. Resveratrol, incubated with non-stimulated mononuclear cells, caused a certain reduction of IL-6, IL-1ra and IL-10, and a moderate increase of TNFα release. On the other hand, resveratrol did not affect cytokine production by cancer cells from both lines. When resveratrol was added to immune and cancer cells jointly, an altered dose-dependent decreased production of the examined cytokines was obtained. These results favor the existence of a mechanism, additional to those already described, that may explain the preventive effect of resveratrol on tumorigenesis.
白藜芦醇是一种天然多酚化合物，主要存在于葡萄及其种子中，作为一种治疗辅助剂，在预防癌症等多种疾病方面受到广泛关注。我们研究了白藜芦醇作为外周血单个核细胞与两种人结肠癌细胞之间免疫对话调节剂的作用，其通过可能改变细胞因子产生来实现。白藜芦醇与非刺激单核细胞孵育，导致 IL-6、IL-1ra 和 IL-10 的一定减少，以及 TNFα 释放的适度增加。另一方面，白藜芦醇对来自两条线的癌细胞的细胞因子产生没有影响。当白藜芦醇添加到免疫和癌细胞中时，获得了所检查细胞因子的改变的剂量依赖性减少的产生。这些结果支持除了已经描述的机制之外，还存在一种可能解释白藜芦醇对肿瘤发生的预防作用的机制。
