Laboratory for Immunology and Hematology Research, Rabin Medical Center, Hasharon Hospital, Petah-Tiqva, the Sackler School of Medicine, Tel-Aviv University, Ramat Aviv, 69978, Israel.
Oncol Res. 2024 Aug 23;32(9):1389-1399. doi: 10.32604/or.2024.049745. eCollection 2024.
Resveratrol (RSV), the primary polyphenol found in grapes, has been revealed to have anti-inflammatory properties by reducing the capacity of the peripheral blood mononuclear cells to produce pro-inflammatory cytokines, including IL-1β, IL-6, IL-1ra and TNFα. Considering the close association between chronic inflammation and cancer development, RSV's immunomodulatory properties are one way by which the polyphenol may inhibit cancer initiation, proliferation, neovascularization, and migration. Resveratrol influences the generation of microtumor environment which is one of the key factors in cancer progress. In addition to immunomodulation, RSV inhibits cancer development by expressing anti-oxidant effects, causing cell cycle arrest, stimulating the function of certain enzymes, and activating cell signaling pathways. The end outcome is one of the various forms of cell death, including apoptosis, pyroptosis, necroptosis, and more, as it has been observed . RSV has been shown to act against cancer in practically every organ, while its effects on colon cancer have been documented more frequently. It is remarkable that longer-term clinical studies that may have established the potential for this natural substance to serve as a therapeutic adjuvant to traditional anti-cancer medications were not prompted by the encouraging outcomes seen with cancer cells treated with non-toxic doses of resveratrol. The current review aims to assess the recent findings about the immunological and anti-cancer characteristics of RSV, with a particular emphasis on cancers of the digestive tract, as a challenge for future clinical research that may contribute to the better prognosis of cancer.
白藜芦醇（RSV）是葡萄中主要的多酚类物质，已被证实具有抗炎特性，它可以降低外周血单个核细胞产生促炎细胞因子的能力，包括 IL-1β、IL-6、IL-1ra 和 TNFα。考虑到慢性炎症与癌症发展之间的密切关系，RSV 的免疫调节特性是多酚类物质抑制癌症起始、增殖、新生血管形成和迁移的一种方式。白藜芦醇影响微肿瘤环境的产生，这是癌症进展的关键因素之一。除了免疫调节，RSV 通过表达抗氧化作用、引起细胞周期停滞、刺激某些酶的功能和激活细胞信号通路来抑制癌症的发展。最终结果是各种形式的细胞死亡之一，包括细胞凋亡、细胞焦亡、细胞坏死等，因为已经观察到 。RSV 已被证明在几乎每个器官中都具有抗癌作用，而其对结肠癌的作用已被更频繁地记录下来。值得注意的是，没有进行更长时间的临床研究来确定这种天然物质作为传统抗癌药物治疗辅助剂的潜力，尽管用无毒剂量的 RSV 处理癌细胞的结果令人鼓舞。本综述旨在评估 RSV 的免疫和抗癌特性的最新发现，特别强调消化道癌症，作为未来临床研究的挑战，这可能有助于改善癌症的预后。
