Unidad de Neuropsicofarmacología Traslacional, Complejo Hospitalario Universitario de Albacete, C/Hermanos Falcó 37, Albacete 02006, Spain.
Psychoneuroendocrinology. 2013 Aug;38(8):1251-8. doi: 10.1016/j.psyneuen.2012.11.008. Epub 2012 Dec 5.
Recent reports suggest that FKBP5 gene and its corresponding FKBP5 protein play a relevant role in the regulation of anxiety and depression in animal models and human stress-related disorders. In the present study, FKBP5 and glucocorticoid receptor (GR) gene and protein expression were analyzed in the amygdala (AMY) of suicide victims (n=13 males, without clinical psychiatric history and non-treated with anxiolytic or antidepressant drugs) and its corresponding controls (n=13 males) by real-time PCR and Western blotting. The results revealed that FKBP5 and GR gene expression were significantly reduced in the AMY (-38% and -48%, respectively) of suicide victims compared with controls. Interestingly, FKBP5 and GR protein expression were also significantly decreased (-41% and -42%, respectively) in the AMY of suicide victims compared with controls. These results suggest that the FKBP5 plays a relevant role in human emotional responses and suggest this receptor as a new promising target in the treatment of suicide behavior.
最近的报告表明，FKBP5 基因及其相应的 FKBP5 蛋白在动物模型和人类应激相关障碍的焦虑和抑郁调节中发挥相关作用。在本研究中，通过实时 PCR 和 Western blot 分析了自杀者（n=13 名男性，无临床精神病史且未用抗焦虑或抗抑郁药物治疗）和相应对照者（n=13 名男性）杏仁核（AMY）中的 FKBP5 和糖皮质激素受体（GR）基因和蛋白表达。结果显示，与对照组相比，自杀者 AMY 中的 FKBP5 和 GR 基因表达显著降低（分别降低 38%和 48%）。有趣的是，与对照组相比，自杀者 AMY 中的 FKBP5 和 GR 蛋白表达也显著降低（分别降低 41%和 42%）。这些结果表明 FKBP5 在人类情感反应中发挥相关作用，并提示该受体是治疗自杀行为的一个有前途的新靶点。
