Peking University HuiLongGuan Clinical Medical School, Beijing HuiLongGuan Hospital, Beijing, 100096, People's Republic of China.
Beijing Suicide Research and Prevention Center, WHO Collaborating Center for Research and Training in Suicide Prevention, Beijing, People's Republic of China.
Eur Arch Psychiatry Clin Neurosci. 2023 Jun;273(4):921-930. doi: 10.1007/s00406-023-01554-5. Epub 2023 Feb 14.
Abnormalities in subcortical brain structures may reflect higher suicide risk in mood disorders, but less is known about its associations for schizophrenia. This cross-sectional imaging study aimed to explore whether the history of suicide attempts was associated with subcortical changes among individuals with schizophrenia. We recruited 44 individuals with schizophrenia and a history of suicide attempts (SZ-SA) and 44 individuals with schizophrenia but without a history of suicide attempts (SZ-NSA) and 44 healthy controls. Linear regression showed that SZ-SA had smaller volumes of the hippocampus (Cohen's d = -0.72), the amygdala (Cohen's d = -0.69), and some nuclei of the amygdala (Cohen's d, -0.57 to -0.72) than SZ-NSA after adjusting for age, sex, illness phase, and intracranial volume. There was no difference in the volume of the subfields of the hippocampus. It suggests the history of suicide attempts is associated with subcortical volume alterations in schizophrenia.
皮质下脑结构异常可能反映出情绪障碍患者的自杀风险更高，但对于精神分裂症患者的皮质下结构异常与自杀的关联，人们了解较少。本横断面影像学研究旨在探讨有自杀未遂史的精神分裂症患者是否存在皮质下结构变化。我们招募了 44 名有自杀未遂史的精神分裂症患者（SZ-SA）、44 名无自杀未遂史的精神分裂症患者（SZ-NSA）和 44 名健康对照者。线性回归显示，调整年龄、性别、疾病阶段和颅内体积后，SZ-SA 的海马体（Cohen's d=-0.72）、杏仁核（Cohen's d=-0.69）和一些杏仁核核团（Cohen's d=-0.57 至-0.72）的体积小于 SZ-NSA。海马体各亚区的体积无差异。这表明自杀未遂史与精神分裂症的皮质下体积改变有关。
