Kagawa Nutrition University, 3-9-21 Chiyoda, Sakado, Saitama 350-0288, Japan.
Prostaglandins Leukot Essent Fatty Acids. 2013 Feb;88(2):179-84. doi: 10.1016/j.plefa.2012.11.004. Epub 2012 Dec 6.
In this study, we administered various diets of stearidonic acid (SDA, 18:4n-3) soybean oil to rats and examined the subsequent blood and organ biochemical parameters. Male Wistar rats (seven rats/group, six groups total) were fed diets supplemented with a test oil for 4 weeks. Diets containing test oils were: FFC diet (fish-oil-free control diet), C diet (control group, assuming a Japanese diet), SDA25 diet (25% 18:4n-3 soybean oil in the C diet), SDA50 (50% 18:4n-3 soybean oil in the C diet), ALA diet (34% flaxseed oil in the C diet), and EPA+DHA diet (34% fish oil in the C diet). The intake of 18:4n-3 showed increased relative efficiency of 20:5n-3 accretions in serum and liver triacylglycerol and significantly decreased the serum triacylglycerol level in rats. The results suggested that the consumption of 18:4n-3 soybean oil may modify the lipid and fatty acid profiles of body fats, even when EPA and DHA derived from fish is consumed.
在这项研究中，我们给大鼠喂食了不同剂量的菜油烯酸（SDA，18:4n-3）大豆油，并检测了随后的血液和器官生化参数。雄性 Wistar 大鼠（每组 7 只，共 6 组）喂食添加了试验油的饮食 4 周。含试验油的饮食包括：FFC 饮食（无鱼油对照饮食）、C 饮食（对照组，假设日本饮食）、SDA25 饮食（C 饮食中添加 25%的 18:4n-3 大豆油）、SDA50（C 饮食中添加 50%的 18:4n-3 大豆油）、ALA 饮食（C 饮食中添加 34%亚麻籽油）和 EPA+DHA 饮食（C 饮食中添加 34%鱼油）。18:4n-3 的摄入量增加了血清和肝脏三酰甘油中 20:5n-3 的相对积累效率，并显著降低了大鼠的血清三酰甘油水平。结果表明，即使摄入源自鱼类的 EPA 和 DHA，18:4n-3 大豆油的消耗也可能改变体脂肪的脂质和脂肪酸谱。
