Department of Biology and Medical Genetics, School of Medicine, University of Rijeka, Braće Branchetta 20, Rijeka 51000, Croatia.
Prostaglandins Leukot Essent Fatty Acids. 2013 Feb;88(2):185-90. doi: 10.1016/j.plefa.2012.11.005. Epub 2012 Dec 7.
We investigated the etiology of the attenuated niacin skin flush response in schizophrenia patients. Skin response to topical niacin of 0.1M, 0.01 M, 0.001 M, and 0.0001 M concentrations was rated using method of volumetric niacin response (VNR) and correlated to two functional A/G polymorphisms in genes: phospholipase A2 group IVA (BanI of the PLA2G4A), and rs689466 of the prostaglandin synthase-2 (PTGS2). We further tested the possible correlation between niacin response and fatty acid (FA) content of red blood cells (RBCs). We detected statistically significant but weak impact of both polymorphisms on niacin flush response in schizophrenia patients. The dosage of the G alleles of both polymorphisms was associated with higher VNR values, although each polymorphic variant accounted for only 1% of the overall flush response variability. Regarding FA content, both n-3 and n-6 polyunsaturated FAs (PUFAs) were significantly reduced in the patient group, but an association with niacin sensitivity was not detected.
我们研究了精神分裂症患者烟碱皮肤潮红反应减弱的病因。使用体积烟碱反应（VNR）方法对 0.1M、0.01M、0.001M 和 0.0001M 浓度的局部烟碱的皮肤反应进行评分，并与基因中两个功能 A/G 多态性相关：磷脂酶 A2 组 IVA（PLA2G4A 的 BanI）和前列腺素合酶-2（PTGS2）的 rs689466。我们进一步测试了烟碱反应与红细胞（RBC）中脂肪酸（FA）含量之间的可能相关性。我们检测到两种多态性对精神分裂症患者烟碱潮红反应均有统计学意义但较弱的影响。两种多态性的 G 等位基因剂量与更高的 VNR 值相关，尽管每个多态性变异仅占总体潮红反应变异性的 1%。关于 FA 含量，患者组中的 n-3 和 n-6 多不饱和脂肪酸（PUFAs）均显著降低，但未发现与烟碱敏感性相关。
