School of Psychology, University of Adelaide, Adelaide, SA, Australia.
Cancer Treat Rev. 2013 May;39(3):297-304. doi: 10.1016/j.ctrv.2012.11.001. Epub 2012 Dec 6.
The aim of this meta-analysis was to assess whether chemotherapy-related cognitive impairment is consistently observed in cancer patients and to identify the areas of cognition affected.
The meta-analysis included 13 studies and examined the effects of chemotherapy on seven different cognitive domains, across five cancer types. It was the intention of this meta-analysis to stringently exclude many studies, allowing for examination of cognition in carefully selected studies of chemotherapy recipients who do not have current mood or anxiety diagnoses (or psychiatric or substance abuse histories), without brain cancer and who have not had radiotherapy or hormone treatment. A moderator analysis examined whether patient age, treatment duration and time since treatment end significantly contributed to chemotherapy-related cognitive impairment.
Evidence for the presence of cognitive impairment following cancer treatment was established for executive function and memory. No relationship was found between cognitive impairment and time since treatment cessation but a significant negative relationship was found for treatment duration. Age had no impact on treatment-related cognitive impairment.
Future research must be conducted on chemotherapy-related cognitive impairment in cancer types such as lymphoma and leukaemia, which have received a moderate amount of attention and colorectal cancer, which has received little attention. This would enable us to determine the extent to which chemotherapy-related cognitive impairment is a universal phenomenon associated with the cancer experience and its treatment regardless of cancer type.
本荟萃分析旨在评估化疗相关性认知障碍是否在癌症患者中普遍存在，并确定受影响的认知领域。
该荟萃分析纳入了 13 项研究，考察了化疗对五种癌症类型中七种不同认知领域的影响。本荟萃分析的目的是严格排除许多研究，仅纳入未患有当前心境或焦虑症（或精神病史或药物滥用史）、无脑癌且未接受过放疗或激素治疗的化疗接受者的精心挑选的研究，以检查认知功能。通过调节分析，考察了患者年龄、治疗持续时间和治疗结束后时间是否对化疗相关性认知障碍有显著影响。
有证据表明，癌症治疗后存在执行功能和记忆方面的认知障碍。认知障碍与治疗结束后时间之间无显著相关性，但与治疗持续时间呈显著负相关。年龄对治疗相关性认知障碍无影响。
未来必须针对淋巴瘤和白血病等得到中度关注的癌症类型以及结直肠癌等受到较少关注的癌症类型开展化疗相关性认知障碍的研究，以确定化疗相关性认知障碍在多大程度上是与癌症经历及其治疗相关的普遍现象，而与癌症类型无关。
