Department of Rare, Immunologic, Hematologic Diseases and Transfusion Medicine, Research Center of Immunopathology and Rare Diseases (CMID), Giovanni Bosco Hospital and University of Turin, Italy.
Autoimmun Rev. 2013 Jun;12(8):821-5. doi: 10.1016/j.autrev.2012.11.006. Epub 2012 Dec 4.
Raynaud's phenomenon (RP) is a clinical sign of precocious abnormal microcirculation and can be considered a major risk factor for the development of connective tissue disease, especially systemic sclerosis (SSc). Nailfold videocapillaroscopy is the most valuable tool for the early diagnosis of SSc and related disorders. It allows classification of capillary abnormalities. Scoring capillaroscopic alterations, which change significantly during patient follow-up, should be systematically used in order to monitor microangiopathy. The effectiveness of the nailfold videocapillaroscopy in allowing an early diagnosis of SSc and monitoring the progression of the disease, and its predictive value of clinical complications make it a powerful tool for clinical evaluation and research.
雷诺现象（RP）是一种早期异常微循环的临床征象，可被视为结缔组织病，尤其是系统性硬化症（SSc）发展的主要危险因素。甲襞毛细血管显微镜检查是 SSc 及相关疾病早期诊断的最有价值的工具。它可以对毛细血管异常进行分类。在患者随访过程中发生显著变化的毛细血管镜改变评分应系统地用于监测微血管病变。甲襞毛细血管镜检查在 SSc 的早期诊断和疾病进展监测方面的有效性及其对临床并发症的预测价值，使其成为临床评估和研究的有力工具。
