Department of Neurosurgery, Tayfur Ata Sökmen Medical Faculty, Mustafa Kemal University, Hatay 31700, Turkey.
J Clin Neurosci. 2013 Mar;20(3):457-61. doi: 10.1016/j.jocn.2012.05.030. Epub 2012 Dec 7.
The aim of this study was to investigate the effect of ceftriaxone treatment against short-term global brain ischemia/reperfusion (I/R) injury in rats. The study was carried out on 30 Wistar-albino rats that were divided into three groups: control group (n=10), I/R group (n=10) and I/R-ceftriaxone group (n=10). Malondialdehyde (MDA) levels were significantly increased in the I/R group in comparison with the control group (p<0.001). MDA was significantly lower in the I/R-ceftriaxone group than in the I/R group (p<0.05). Superoxide dismutase activity was significantly decreased in the I/R group and increased in the I/R-ceftriaxone group as compared with the control group. Glutathione peroxidase activity was significantly decreased in the I/R group and increased in the I/R-ceftriaxone group as compared with the I/R group and the control. Histopathologically, ceftriaxone provided morphological improvement compared with the I/R group. We concluded that ceftriaxone has neuron-protective effects due to its antioxidant properties as shown by a decrease in MDA overproduction and histological improvement in brain tissue.
本研究旨在探讨头孢曲松治疗对大鼠短期全脑缺血/再灌注（I/R）损伤的影响。该研究在 30 只 Wistar 白化大鼠中进行，将其分为三组：对照组（n=10）、I/R 组（n=10）和 I/R-头孢曲松组（n=10）。与对照组相比，I/R 组丙二醛（MDA）水平显著升高（p<0.001）。与 I/R 组相比，I/R-头孢曲松组 MDA 水平显著降低（p<0.05）。与对照组相比，I/R 组超氧化物歧化酶活性显著降低，I/R-头孢曲松组活性增加。与 I/R 组相比，I/R-头孢曲松组谷胱甘肽过氧化物酶活性降低，与对照组相比，I/R-头孢曲松组活性增加。组织病理学检查结果表明，与 I/R 组相比，头孢曲松提供了形态学改善。我们得出结论，头孢曲松具有神经保护作用，这与其抗氧化特性有关，表现为 MDA 过度产生减少和脑组织的组织学改善。
