Parpura Vladimir, Verkhratsky Alexei
Department of Neurobiology, University of Alabama, Birmingham, AL 35294, USA.
Biochim Biophys Acta. 2013 Jul;1833(7):1625-31. doi: 10.1016/j.bbamcr.2012.11.023. Epub 2012 Dec 4.
Pathology of the brain is caused by the deficiency in tissue homeostasis. As the main homeostatic element of the mammalian nervous system is represented by astrocytes, these glial cells are involved in many, if not all, brain disorders. Diseased astrocytes undergo a variety of morphological and functional changes, including deregulation of calcium dynamics. To rectify undesirable changes in astrocytes and/or neurones that occur in disease, we postulate the future use of nanotechnology-based therapeutics. Carbon nanotubes emerged as one of the most promising advanced nanomaterials for use in neuroprosthesis. Recently, they have been used to affect morpho-functional characteristics of astrocytes. This article is part of a Special Issue entitled: 12th European Symposium on Calcium.
脑组织病理学是由组织稳态失衡引起的。由于哺乳动物神经系统的主要稳态元素是星形胶质细胞，这些神经胶质细胞即使不是参与了所有脑部疾病，也参与了许多脑部疾病。患病的星形胶质细胞会经历各种形态和功能变化，包括钙动力学失调。为了纠正疾病中星形胶质细胞和/或神经元出现的不良变化，我们推测未来会使用基于纳米技术的疗法。碳纳米管已成为用于神经假体最有前景的先进纳米材料之一。最近，它们已被用于影响星形胶质细胞的形态功能特性。本文是名为“第12届欧洲钙研讨会”的特刊的一部分。
