Medical Genomics Research Center, KRIBB, Gwahangno, Yuseong-gu, Daejeon 305-806, Republic of Korea.
Gene. 2013 Apr 10;518(1):194-200. doi: 10.1016/j.gene.2012.11.032. Epub 2012 Dec 7.
Integrated analysis of DNA methylation and gene expression can reveal specific epigenetic patterns that are important during carcinogenesis. We built an integrated database of DNA methylation and gene expression termed MENT (Methylation and Expression database of Normal and Tumor tissues) to provide researchers information on both DNA methylation and gene expression in diverse cancers. It contains integrated data of DNA methylation, gene expression, correlation of DNA methylation and gene expression in paired samples, and clinicopathological conditions gathered from the GEO (Gene Expression Omnibus) and TCGA (The Cancer Genome Atlas). A user-friendly interface allows users to search for differential DNA methylation by either 'gene search' or 'dataset search'. The 'gene search' returns which conditions are differentially methylated in a gene of interest, while 'dataset search' returns which genes are differentially methylated in a condition of interest based on filtering options such as direction, DM (differential methylation value), and p-value. MENT is the first database which provides both DNA methylation and gene expression information in diverse normal and tumor tissues. Its user-friendly interface allows users to easily search and view both DNA methylation and gene expression patterns. MENT is freely available at http://mgrc.kribb.re.kr:8080/MENT/.
整合 DNA 甲基化和基因表达分析可以揭示在癌变过程中非常重要的特定表观遗传模式。我们构建了一个称为 MENT（正常组织和肿瘤组织的甲基化和表达数据库）的 DNA 甲基化和基因表达综合数据库，为研究人员提供了不同癌症中 DNA 甲基化和基因表达的信息。它包含从 GEO（基因表达综合数据库）和 TCGA（癌症基因组图谱）中收集的 DNA 甲基化、基因表达、配对样本中 DNA 甲基化和基因表达的相关性以及临床病理条件的综合数据。一个用户友好的界面允许用户通过“基因搜索”或“数据集搜索”来搜索差异 DNA 甲基化。“基因搜索”返回在感兴趣的基因中哪些条件存在差异甲基化，而“数据集搜索”则根据方向、DM（差异甲基化值）和 p 值等过滤选项，返回在感兴趣的条件中哪些基因存在差异甲基化。MENT 是第一个提供不同正常和肿瘤组织中 DNA 甲基化和基因表达信息的数据库。其用户友好的界面允许用户轻松搜索和查看 DNA 甲基化和基因表达模式。MENT 可在 http://mgrc.kribb.re.kr:8080/MENT/ 免费获取。
