School of Biological Sciences, Queen's University Belfast, 97 Lisburn Rd., Belfast, Ireland.
Int J Parasitol. 2013 Mar;43(3-4):283-91. doi: 10.1016/j.ijpara.2012.11.004. Epub 2012 Dec 5.
The success of helminth parasites is partly related to their ability to modulate host immune responses towards an anti-inflammatory/regulatory phenotype. This ability resides with the molecules contained in the secretome of various helminths that have been shown to interact with host immune cells and influence their function. Consequently, there exists a unique opportunity to exploit these molecules for the prophylactic and therapeutic treatment of human pro- and auto-inflammatory disorders (for example septic shock, transplant rejection and autoimmune disease). In this review, we describe the mechanisms used by the trematode parasite, Fasciola hepatica, to modulate the immune responses of its host and discuss the potent immune-modulatory effects of three individual molecules within the secretome; namely cathepsin L1, peroxiredoxin and helminth defence molecule. With a focus on the requirements from industry, we discuss the strategies by which these molecules may be clinically developed to control human immune responses in a way that is conducive to the prevention of immune-mediated diseases.
寄生虫的成功在一定程度上与其调节宿主免疫反应向抗炎/调节表型的能力有关。这种能力存在于各种寄生虫的分泌组中的分子中，这些分子已被证明与宿主免疫细胞相互作用并影响其功能。因此，存在利用这些分子预防和治疗人类前炎症和自身炎症性疾病（例如败血症休克、移植排斥和自身免疫性疾病）的独特机会。在这篇综述中，我们描述了吸虫寄生虫 Fasciola hepatica 用来调节宿主免疫反应的机制，并讨论了分泌组中三个分子的强大免疫调节作用；即组织蛋白酶 L1、过氧化物还原酶和寄生虫防御分子。我们重点讨论了工业界的要求，讨论了这些分子可能在临床上得到开发的策略，以控制人类免疫反应，从而有利于预防免疫介导的疾病。
