Webster J, Williams B D, Smith A P, Hall M, Jessop J D
Department of Medicine, University Hospital of Wales, Heath Park, Cardiff.
Ann Rheum Dis. 1990 Mar;49(3):181-3. doi: 10.1136/ard.49.3.181.
A 50 year old woman presented with pneumococcal septicaemia, septic arthritis, and a lobar pneumonia and was subsequently diagnosed as having systemic lupus erythematosus. The blood film and splenic 99mTc sulphur colloid uptake were normal, although selective functional hyposplenism was shown by the impaired clearance of immunoglobulin coated erythrocytes. Systemic lupus erythematosus presenting with fulminating pneumococcal sepsis in the presence of selective defects in spleen function is previously unreported.
一名50岁女性因肺炎球菌败血症、化脓性关节炎和大叶性肺炎就诊,随后被诊断为系统性红斑狼疮。尽管免疫球蛋白包被红细胞清除功能受损显示有选择性功能性脾功能减退,但血涂片和脾脏99mTc硫胶体摄取正常。以前未见有报道系统性红斑狼疮在存在脾脏功能选择性缺陷的情况下出现暴发性肺炎球菌败血症。