Le Luyer B, Mougenot J F, Mashako L, Chapoy P, Olives J P, Morali A, Chevallier B, Ginies J L, Dupont C, Dagorne M
Services de: Gastro-Entérologie pédiatrique, Centre Hospitalier, Le Havre.
Arch Fr Pediatr. 1990 Jan;47(1):65-8.
Eighty-three children presenting with symptomatic gastro-esophageal reflux (GER) (48 males, 35 females, aged 15 days to 57 months (mean = 7 months) were assessed by pH monitoring. All showed acid pathological GER on the 3 hours post-prandial esophageal pH measurement (% of time at pH less than 4 greater than 4.2) and all had a second pH measurement within the following 3 hours after intake of a single (5 ml) dose of sodium alginate (AGS). AGS administration was followed by a highly significant reduction (p less than 0.00001) of all pH measurement variables: a) Percentage of time spent at pH less than 4 returned to normal with a mean 11.7% to 4.8%; that is a 52.5% improvement (median); b) Total number of reflux reduced on average from 8.9 to 5.0: that is a 35% improvement (median); c) Mean duration of reflux reduced on average for 4 to 2 min; that is a 60% improvement (median). In 76 patients hourly monitoring of % of time spent at pH less than 4 shows that hourly improvement persists.
八十三名有症状的胃食管反流（GER）患儿（48名男性，35名女性，年龄15天至57个月（平均7个月））通过pH监测进行评估。所有患儿在餐后3小时食管pH测量（pH值低于4的时间百分比大于4.2）时均显示酸性病理性GER，并且在摄入单剂量（5毫升）海藻酸钠（AGS）后的接下来3小时内均进行了第二次pH测量。给予AGS后，所有pH测量变量均出现极显著降低（p小于0.00001）：a）pH值低于4的时间百分比恢复正常，平均从11.7%降至4.8%；即改善了52.5%（中位数）；b）反流总数平均从8.9次降至5.0次；即改善了35%（中位数）；c）反流平均持续时间从4分钟降至2分钟；即改善了60%（中位数）。在76名患者中，每小时对pH值低于4的时间百分比进行监测显示，每小时的改善持续存在。
